Searched for malaria.

1. Christian Lengeler: Malaria breitet sich wieder aus [Radio Broadcast] (Publications)

   Christian Lengeler: Malaria breitet sich wieder aus [Radio Broadcast]

   Relevance:

   Das Ziel der Weltgesundheitsorganisation: Malaria bis 2050 auszurotten. Noch immer sterben rund eine halbe Million Menschen jährlich an Malaria, die Zahl der Toten sinkt seit einigen Jahren nicht mehr

2. Die Falciparum-Malaria in der Schweiz: ein Problem der Intensivmedizin? (Publications)

   Die Falciparum-Malaria in der Schweiz: ein Problem der Intensivmedizin?

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   the period 1972-1976, 5 of 17 patients admitted to the Cantonal Hospital, Basel, for falciparum malaria had to be treated in the intensive care unit. Two patients died. None had performed regular chem [...] several days had elapsed between onset of symptoms and diagnosis. The importance of information on malaria to tourists and physicians is stressed.

3. Epidemiologie und Klinik der Malaria in der Schweiz (Publications)

   Epidemiologie und Klinik der Malaria in der Schweiz

   Relevance:

   thirds of all cases of malaria in Switzerland are imported from Africa. Accordingly, malignant malaria is more frequently diagnosed in Switzerland than tertian malaria. Malignant malaria usually presents atypically [...] shock. The lethality is high. The majority of Swiss travellers are not protected effectively against malaria. A group particularly at risk are tourists of 20--30 years of age. It is suggested that travel agencies [...] the medical profession should intensify public information...

4. Das Antiarrhythmikum Chinidin als Alternative in der Behandlung der schweren Falciparum-Malaria (Publications)

   Das Antiarrhythmikum Chinidin als Alternative in der Behandlung der schweren Falciparum-Malaria

   Relevance:

   quinidine, usually stocked by hospitals, is an alternative drug for malaria treatment. We report the cases of two patients with severe malaria imported from Kenya. They were treated first with intravenous quinidine [...] Parenteral quinine is the most effective treatment for severe falciparum malaria. It is not easily available in Switzerland and so dangerous delays treating patients may occur. The antiarrhythmic drug [...] mg/kg b.w./die of quinidine given intravenously seems to be an adequate...

5. The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite <em>Plasmodium falciparum</em> (Publications)

   The ApiAP2 factor PfAP2-HC is an integral component of heterochromatin in the malaria parasite <em>Plasmodium falciparum</em>

   Relevance:

   Malaria parasites undergo a complex life cycle in the human host and the mosquito vector. The ApiAP2 family of DNA-binding proteins plays a dominant role in parasite development and life cycle progression [...] maintenance. In summary, our findings reveal PfAP2-HC as a core component of heterochromatin in malaria parasites and identify unexpected properties and substantial functional divergence among the members

6. Investigation of heterochromatin protein 1 function in the malaria parasite <em>Plasmodium falciparum</em> using a conditional domain deletion and... (Publications)

   Investigation of heterochromatin protein 1 function in the malaria parasite <em>Plasmodium falciparum</em> using a conditional domain deletion and swapping approach

   Relevance:

   offers a tool for further studies on epigenetic regulation and life cycle decision in malaria parasites.IMPORTANCE Malaria is caused by unicellular Plasmodium species parasites that repeatedly invade and replicate [...] The human malaria parasite Plasmodium falciparum encodes a single ortholog of heterochromatin protein 1 (PfHP1) that plays a crucial role in the epigenetic regulation of various survival-related processes [...] domain and CSD of HP1 are functionally conserved between P....

7. Zerebrale Malaria tropica mit Schwarzwasserfieber. Ein aktuelles diagnostisches und therapeutisches Problem (Publications)

   Zerebrale Malaria tropica mit Schwarzwasserfieber. Ein aktuelles diagnostisches und therapeutisches Problem

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8. Bayesian spatial models applied to malaria epidemiology (Publications)

   Bayesian spatial models applied to malaria epidemiology

   Relevance:

   scaling-up. Contemporary information on malaria prevalence for this work was provided mostly by Malaria Indicator Surveys (MIS) and Demographic Health Surveys (DHS) with malaria modules. MIS are nationally rep [...] impressive increases in international funding for malaria prevention, control, and elimination, which have led to tremendous expansion in implementing national malaria control programs (NMCPs). Common interventions [...] (MDG) 6 aims to halve malaria incidence by 2015 as compared to...

9. Structural basis of malaria RIFIN binding by LILRB1-containing antibodies (Publications)

   Structural basis of malaria RIFIN binding by LILRB1-containing antibodies

   Relevance:

   Some Plasmodium falciparum repetitive interspersed families of polypeptides (RIFINs)—variant surface antigens that are expressed on infected erythrocytes1—bind to the inhibitory receptor LAIR1, and in

10. Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults (Publications)

    Proteome-wide analysis of a malaria vaccine study reveals personalized humoral immune profiles in Tanzanian adults

    Relevance:

    (Pf) sporozoites (PfSPZ Vaccine) and protective efficacy assessed by homologous controlled human malaria infection (CHMI). Serum immunoglobulin G (IgG) responses were analyzed longitudinally using a Pf [...] first insights into naturally acquired and PfSPZ Vaccine-induced whole parasite antibody profiles in malaria pre-exposed Africans. Immunoreactivity was identified against 2,239 functionally diverse Pf proteins