Feasibility and acceptability of injectable artesunate for the treatment of severe malaria in the Democratic Republic of Congo (Publications)
The Democratic Republic of the Congo (DRC) changed its national policy for the treatment of severe malaria in both children and adults in 2012 from intravenous quinine to injectable artesunate. The country [...] deploy nationwide injectable artesunate as the preferred treatment for the management of severe malaria. To support this process, the feasibility and acceptability of the use of injectable artesunate in [...] CONCLUSIONS: These findings show that the use of injectable artesunate for the...
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and... (Publications)
baseline values for clearance in patients from Sub-Saharan African countries with uncomplicated malaria treated with artemisinin-based combination therapies (ACTs). METHODS: A literature review in PubMed
Strategies and approaches to vector control in nine malaria-eliminating countries: a cross-case study analysis (Publications)
BACKGROUND: There has been progress towards malaria elimination in the last decade. In response, WHO launched the Global Technical Strategy (GTS), in which vector surveillance and control play important [...] important roles. Country experiences in the Eliminating Malaria Case Study Series were reviewed to identify success factors on the road to elimination using a cross-case study analytic approach. METHODS: Reports [...] Namibia, Philippines, Sri Lanka, Turkey, Turkmenistan). A conceptual...
The time-course of protection of the RTS,S vaccine against malaria infections and clinical disease (Publications)
BACKGROUND: Recent publications have reported follow-up of the RTS,S/AS01 malaria vaccine candidate Phase III trials at 11 African sites for 32 months (or longer). This includes site- and time-specific [...] Bayesian fitting of these model predictions to the site- and time-specific incidence of clinical malaria over 32 months (or longer) of follow-up. Using the same stochastic models, projections of clinical
Malaria transmission dynamics surrounding the first nationwide long-lasting insecticidal net distribution in Papua New Guinea (Publications)
BACKGROUND: The major malaria vectors of Papua New Guinea exhibit heterogeneities in distribution, biting behaviour and malaria infection levels. Long-lasting, insecticide-treated nets (LLINs), distributed [...] distributed as part of the National Malaria Control Programme, are the primary intervention targeting malaria transmission. This study evaluated the impact of LLINs on anopheline density, species composition [...] n, feeding behaviour, and malaria transmission. METHODS: Mosquitoes were...
Epidemiology of malaria in the Taabo health and demographic surveillance system, south-central Côte d'Ivoire (Publications)
epidemiology of malaria is essential for the design and implementation of setting-specific control and elimination efforts. In Cote d'Ivoire, new initiatives are underway to reduce the burden of malaria, which [...] which requires high-quality longitudinal data. The epidemiology of malaria was studied in the Taabo health and demographic surveillance system (HDSS) in south-central Cote d'Ivoire and implications for control [...] 6 and 62.8 % versus 42.6 and 51.2 %; respectively, in 2010 and 2011;...
Encouraging impact following 2.5 years of reinforced malaria control interventions in a hyperendemic region of the Republic of Guinea (Publications)
multi-component malaria control intervention significantly reduced the prevalence of malaria in the sous-prefectures of intervention while also increasing the coverage of bed nets. However, malaria prevalence [...] BACKGROUND: Malaria is one of the principal causes of morbidity and mortality in the Republic of Guinea, particularly in the highly endemic regions. To assist in malaria control efforts, a multi-component [...] nent malaria control intervention was implemented in the hyperendemic...
The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a... (Publications)
BACKGROUND: Iron deficiency (ID) and malaria co-exist in tropical regions and both contribute to high rates of anaemia in young children. It is unclear whether iron fortification combined with intermittent [...] intermittent preventive treatment (IPT) of malaria would be an efficacious strategy for reducing anaemia in young children. METHODS: A 9-month cluster-randomised, single-blinded, placebo-controlled intervention [...] out in children aged 12-36 months in south-central Cote d'Ivoire, an...
Health worker compliance with a 'test and treat' malaria case management protocol in Papua New Guinea (Publications)
current/recently febrile patients for malaria infection by RDT or microscopy in the absence of acute malaria symptoms, reserving recommended antimalarials for confirmed malaria cases only and choosing to clinically [...] Across the two surveys, 77.6% of patients were tested for malaria infection by rapid diagnostic test (RDT) or microscopy, 65.6% of confirmed malaria cases were prescribed the correct antimalarials and 15 [...] The Papua New Guinea (PNG) Department of Health introduced a 'test...
The epidemiology of residual <em>Plasmodium falciparum</em> malaria transmission and infection burden in an African city with high coverage of... (Publications)
the end of 2012. METHODS: Three rounds of city-wide, cluster-sampled cross-sectional surveys of malaria parasite infection status, spanning 2010 to 2012, were complemented by two series of high-resolution