Malaria Vaccines (Page)
https://www.swisstph.ch/en/topics/malaria/malaria-vaccines
developing resistance to existing malaria drugs, and mosquitoes are developing resistance to insecticides. Malaria vaccines are potential new tools in combating malaria by targeting several different stages [...] decision making boards. Malaria Basic Malaria Research Antimalarial Drug Development Mosquito Biology and Control Project Highlights Health Impact and Cost-Effectiveness of Malaria Vaccines Swiss TPH has [...] Malaria Vaccines Recently, the malaria burden was successfully reduced as a...
CARAMAL | Swiss TPH Malaria Projects (Page)
https://www.swisstph.ch/en/about/med/medicines-implementation-research/caramal
CARAMAL - Community Access to Rectal Artesunate for Malaria Many malaria deaths occur in places where people have poor access to preventive and curative health services. Prompt access to quality care is [...] severe childhood diseases, among which severe malaria is particularly frequent in endemic areas of sub-Saharan Africa. Where parenteral treatment of severe malaria is not available, for example at the level [...] of care for severe malaria can be provided. Since 2018, two RAS products have...
The candidate blood-stage malaria vaccine P27A induces a robust humoral response in a fast track to the field phase I trial in exposed and non exposed... (Publications)
The present project aimed at evaluating the safety and immunogenicity of P27A peptide vaccine in malaria non-exposed European and exposed African adults. Methods: This study was designed as a staggered [...] GLA-SE (2.5 or 5mug), or control rabies vaccine (Verorab(R)) were administered intramuscularly to 16 malaria non-exposed and 40 exposed subjects on days 0, 28 and 56. Local and systemic adverse events (AEs) [...] an ADCI dependent mechanism. Incidence of AEs and antibody responses were...
Safety, immunogenicity, and protective efficacy against controlled human malaria infection of<em> Plasmodium falciparum</em> sporozoites vaccine in... (Publications)
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI) of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ) (PfSPZ Challenge) to try to reduce time [...] time and costs of developing PfSPZ Vaccine to prevent malaria in Africa. Immunization with five doses at 0, 4, 8, 12, and 20 weeks of 2.7 x 10(5) PfSPZ of PfSPZ Vaccine gave 65% vaccine efficacy (VE) at [...] and controls. Antibody responses to Pf circumsporozoite protein were...
UCT943, a next generation <em>Plasmodium falciparum</em> PI4K inhibitor preclinical candidate for the treatment of malaria (Publications)
drug candidate inhibiting Plasmodium phosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical development. In an effort to identify the next generation of PI4K inhibitors, [...] single-exposure radical cure and prophylaxis (SERCaP) to treat, prevent and block the transmission of malaria.
Malaria and the 'last' parasite: how can technology help? (Publications)
Malaria, together with HIV/AIDS, tuberculosis and hepatitis are the four most deadly infectious diseases globally. Progress in eliminating malaria has saved millions of lives, but also creates new challenges [...] accurate detection of malaria infections, both in symptomatic and asymptomatic individuals are needed. In this review, the current progress in developing new diagnostic tools to fight malaria is presented. An [...] An ideal rapid test for malaria elimination is envisioned with examples...