Assessing the effects of malaria interventions on the geographical distribution of parasitaemia risk in Burkina Faso (Publications)
nationally representative household malaria survey in 2010/2011. The survey collected among others, information on malaria interventions, treatment choices and malaria parasite prevalence in children aged [...] residual spray (IRS), artemisinin-based combination therapy (ACT) coverage associated with childhood malaria parasite risk at national and sub-national level, after taking into account geographical disparities [...] where interventions are being effective. These outputs are valuable tools...
Operational strategies of anti-malarial drug campaigns for malaria elimination in Zambia's southern province: a simulation study (Publications)
strategies for parasite clearance in southern province. METHODS: OpenMalaria, a discrete-time, individual-based stochastic model of malaria, was parameterized for the study area to simulate anti-malarial drug [...] BACKGROUND: Malaria elimination requires reducing both the potential of mosquitoes to transmit parasites to humans and humans to transmit parasites to mosquitoes. To achieve this goal in Southern province
Policy analysis for deciding on a malaria vaccine RTS,S in Tanzania (Publications)
stakeholders in Tanzania to assess malaria treatment policy changes and to draw lessons for malaria vaccine adoption. RESULTS: The decision-making process for adopting malaria interventions and new vaccines [...] policy makers and stimulate the decision-making process. In the case of the proposed introduction of malaria vaccines in Tanzania, a specific framework for decision-making will speed up the administrative process [...] Promoting factors include; epidemiological and intervention...
Identification of new human malaria parasite <em>Plasmodium falciparum</em> dihydroorotate dehydrogenase inhibitors by pharmacophore and... (Publications)
Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), a key enzyme in the de novo pyrimidine biosynthesis pathway, which the Plasmodium falciparum relies on exclusively for survival, has emerg
Spatially aggregated clusters and scattered smaller loci of elevated malaria vector density and human infection prevalence in urban Dar es Salaam,... (Publications)
density and eight of malaria infection prevalence were detected over both phases. Only a third of vectors were collected in hotspots in phase 1 (30 %) and phase 2 (33 %). Malaria prevalence hotspots accounted [...] BACKGROUND: Malaria transmission, primarily mediated by Anopheles gambiae, persists in Dar es Salaam (DSM) despite high coverage with bed nets, mosquito-proofed housing and larviciding. New or improved [...] improved vector control strategies are required to eliminate malaria from...
Estimating malaria transmission intensity from <em>Plasmodium falciparum</em> serological data using antibody density models (Publications)
BACKGROUND: Serological data are increasingly being used to monitor malaria transmission intensity and have been demonstrated to be particularly useful in areas of low transmission where traditional measures
The effects of an oil and wheat flour fortification program on pre-school children and women of reproductive age living in Côte d'Ivoire, a... (Publications)
Anemia and micronutrient deficiencies are widespread in sub-Saharan Africa, but the impact of food fortification is still debated. The objective of this study was to estimate the iron and vitamin A st
Comparative performance of three experimental hut designs for measuring malaria vector responses to insecticides in Tanzania (Publications)
BACKGROUND: Experimental huts are simplified, standardized representations of human habitations that provide model systems to evaluate insecticides used in indoor residual spray (IRS) and long-lasting
Assessment of parental perception of malaria vaccine in Tanzania (Publications)
and willingness to use malaria vaccines and to provide policy makers with evidence-based information on the best strategies to engage communities to manage the introduction of malaria vaccine in Tanzania [...] variables of interests were awareness and willingness to use a malaria vaccine. The main outcome measure was willingness to use a malaria vaccine. Logistic regression was used to examine the influence [...] BACKGROUND: Clinical trials of the RTS,S malaria vaccine have completed Phase III...