Entomological survey of sibling species in the <em>Anopheles funestus</em> group in Tanzania confirms the role of <em>Anopheles parensis</em> as a... (Publications)
better understand the ecology and vectorial capacity of this and other secondary malaria vectors in the region to improve malaria control. [...] BACKGROUND: Malaria transmission in Tanzania is driven by mosquitoes of the Anopheles gambiae complex and Anopheles funestus group. The latter includes An. funestus s.s., an anthropophilic vector, which [...] provides the initial results of a cross-country study of the species composition, distribution and malaria transmission potential of members of...
Screening of malaria infections in human blood samples with varying parasite densities and anaemic conditions using AI-Powered mid-infrared... (Publications)
accurately detect malaria infections across varying parasite densities and anaemic conditions. METHODS: Plasmodium falciparum strains NF54 and FCR3 were cultured and mixed with blood from 70 malaria-free individuals [...] unseen datasets to detect malaria at various parasitaemia levels and anaemic conditions. Additionally, these classifiers were tested on samples from a population survey in malaria-endemic villages of southeastern [...] complication in malaria patients. CONCLUSION: These...
A review of applications and limitations of using aquatic macroinvertebrate predators for biocontrol of the African malaria mosquito, <em>Anopheles... (Publications)
form malaria vector larval habitats. The presence of these predators in malaria vector larval habitats can negatively impact on development, adult body size, fecundity, and longevity of the malaria vectors [...] predators on malaria vectors warrant their consideration as biocontrol agents in an integrated program to combat malaria. However, the use of these macroinvertebrate predators in malaria biocontrol is [...] We reviewed the literature on the use of aquatic macroinvertebrate predators for...
Embedded-deep-learning-based sample-to-answer device for on-site malaria diagnosis (Publications)
digital image transmission. This method can set a new paradigm for on-site malaria diagnosis. The miLab™ algorithm for malaria detection achieved a total accuracy of 98.86% for infected red blood cell (RBC) [...] Improvements in digital microscopy are critical for the development of a malaria diagnosis method that is accurate at the cellular level and exhibits satisfactory clinical performance. Digital microscopy [...] 92.21%. Based on these results, miLab™ can become a reliable and efficient...
Field evaluation of a volatile pyrethroid spatial repellent and etofenprox treated clothing for outdoor protection against forest malaria vectors in... (Publications)
Cambodia's goal to eliminate malaria by 2025 is challenged by persistent transmission in forest and forest fringe areas, where people are exposed to Anopheles mosquito bites during the day and night. Volatile [...] the potential to reduce outdoor and daytime Anopheles biting, offering valuable contributions to malaria elimination efforts in Cambodia and the Greater Mekong Subregion, contingent upon achieving effective
Identification of potent and reversible piperidine carboxamides that are species-selective orally active proteasome inhibitors to treat malaria (Publications)
Malaria remains a global health concern as drug resistance threatens treatment programs. We identified a piperidine carboxamide (SW042) with anti-malarial activity by phenotypic screening. Selection of [...] Pf_proteasome β5 active-site (Pfβ5). A potent analog (SW584) showed efficacy in a mouse model of human malaria after oral dosing. SW584 had a low propensity to generate resistance (minimum inoculum for resistance
Seasonal malaria chemoprevention and the spread of <em>Plasmodium falciparum </em>quintuple-mutant parasites resistant to sulfadoxine-pyrimethamine: a... (Publications)
BACKGROUND: Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine prevents millions of clinical malaria cases in children younger than 5 years in Africa's Sahel region [...] of quintuple-mutant parasites and the clinical consequences. METHODS: We used an individual-based malaria transmission model with explicit parasite dynamics and drug pharmacological models to identify and [...] deployment strategies. We estimated the impact of this spread on SMC effectiveness...
Climate change, malaria and neglected tropical diseases: a scoping review (Publications)
To explore the effects of climate change on malaria and 20 neglected tropical diseases (NTDs), and potential effect amelioration through mitigation and adaptation, we searched for papers published from [...] 1543 full-text papers were assessed. Of 511 papers meeting the inclusion criteria, 185 studied malaria, 181 dengue and chikungunya and 53 leishmaniasis; other NTDs were relatively understudied. Mitigation [...] (34%) and adaption strategies in 24 (5%). Amplitude and direction of effects of...
Severe outcomes of malaria in children under time-varying exposure (Publications)
Plasmodium falciparum severe malaria dataset to better understand the relationship between prevalence and incidence of malaria pediatric hospitalizations - a proxy of malaria severe outcomes- in East-Africa [...] In malaria epidemiology, interpolation frameworks based on available observations are critical for policy decisions and interpreting disease burden. Updating our understanding of the empirical evidence [...] dynamics, and subsequent protection patterns in children, substantially...