<em>Plasmodium falciparum</em> merozoite surface protein 1 as asexual blood stage malaria vaccine candidate (Publications)
INTRODUCTION: Malaria represents a tremendous public health challenge in tropical and sub-tropical regions, and currently deployed control strategies are likely insufficient to drive elimination of malaria. Development [...] Development and improvement of malaria vaccines might be key to reduce disease burden. Vaccines targeting asexual blood stages of the parasite have shown limited efficacy when studied in human trials conducted [...] as one of the most promising approaches to provide immune...
Development of WHO recommendations for the final phase of elimination and prevention of re-establishment of malaria (Publications)
that all affected countries work toward the elimination of malaria, even those still experiencing a high burden of disease. However, malaria programs in the final phase of elimination or those working [...] and quality-controlled malaria guidelines. The WHO convened an external guideline development group to formulate recommendations for interventions to reduce or prevent malaria transmission in areas with [...] with very low- to low-transmission levels and those that have eliminated malaria....
Delayed cerebellar ataxia induced by <em>Plasmodium falciparum</em> malaria: a rare complication (Publications)
KEY CLINICAL MESSAGE: In endemic areas, malaria-induced cerebellar ataxia should be suspected in patients presenting with neurological disorders including slurred speech, tremors, and a sense of imbalance [...] ions, investigations, and outcomes of a patient developed delayed cerebellar ataxia following a malaria infection: an unusual complication of the disease. This report highlights the diagnostic challenges
Assessing caregivers' perceptions of treatment-seeking for suspected severe malaria in the Democratic Republic of the Congo (Publications)
BACKGROUND: Malaria remains a major public health issue in the Democratic Republic of the Congo (DRC), accounting for 44% deaths among outpatient visits in children
Effects of climate variability on malaria transmission in southern Côte d'Ivoire, West Africa (Publications)
variables and malaria transmission in Côte d’Ivoire. We used the VECTRI model to predict malaria transmission in southern Côte d’Ivoire. First, we tested the suitability of VECTRI in modeling malaria transmission [...] Malaria continues to be a major public health concern with a substantial burden in Africa. Even though it has been widely demonstrated that malaria transmission is climate-driven, there have been very [...] rate (EIR) from the VECTRI model was well correlated with the observed mal...
Sporozoite immunization: innovative translational science to support the fight against malaria (Publications)
'sporozoites,' 'malaria,' and 'vaccines.' EXPERT OPINION: First generation (radiation-attenuated) PfSPZ vaccines are safe, well tolerated, 80-100% efficacious against homologous controlled human malaria infection [...] INTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly [...] effective vaccine is urgently needed, especially for Plasmodium...
Acceptability of pre-referral rectal artesunate for severe malaria in children under 5 years by health workers and caregivers in the Democratic... (Publications)
BACKGROUND: For children below 6 years with suspected severe malaria attending a health care provider unable to provide parenteral malaria treatment, pre-referral rectal artesunate (RAS) is recommended [...] countries are in the process of rolling out quality-assured RAS for pre-referral treatment of severe malaria at community-level. The success of RAS depends, among other factors, on the acceptability of RAS [...] comprehensive multi-country observational research project Community Access to...
