Seasonal malaria chemoprevention and the spread of <em>Plasmodium falciparum </em>quintuple-mutant parasites resistant to sulfadoxine-pyrimethamine: a... (Publications)
BACKGROUND: Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine prevents millions of clinical malaria cases in children younger than 5 years in Africa's Sahel region [...] of quintuple-mutant parasites and the clinical consequences. METHODS: We used an individual-based malaria transmission model with explicit parasite dynamics and drug pharmacological models to identify and [...] deployment strategies. We estimated the impact of this spread on SMC effectiveness...
Entomological survey of sibling species in the <em>Anopheles funestus</em> group in Tanzania confirms the role of <em>Anopheles parensis</em> as a... (Publications)
better understand the ecology and vectorial capacity of this and other secondary malaria vectors in the region to improve malaria control. [...] BACKGROUND: Malaria transmission in Tanzania is driven by mosquitoes of the Anopheles gambiae complex and Anopheles funestus group. The latter includes An. funestus s.s., an anthropophilic vector, which [...] provides the initial results of a cross-country study of the species composition, distribution and malaria transmission potential of members of...
Screening of malaria infections in human blood samples with varying parasite densities and anaemic conditions using AI-Powered mid-infrared... (Publications)
accurately detect malaria infections across varying parasite densities and anaemic conditions. METHODS: Plasmodium falciparum strains NF54 and FCR3 were cultured and mixed with blood from 70 malaria-free individuals [...] unseen datasets to detect malaria at various parasitaemia levels and anaemic conditions. Additionally, these classifiers were tested on samples from a population survey in malaria-endemic villages of southeastern [...] complication in malaria patients. CONCLUSION: These...
A review of applications and limitations of using aquatic macroinvertebrate predators for biocontrol of the African malaria mosquito, <em>Anopheles... (Publications)
form malaria vector larval habitats. The presence of these predators in malaria vector larval habitats can negatively impact on development, adult body size, fecundity, and longevity of the malaria vectors [...] predators on malaria vectors warrant their consideration as biocontrol agents in an integrated program to combat malaria. However, the use of these macroinvertebrate predators in malaria biocontrol is [...] We reviewed the literature on the use of aquatic macroinvertebrate predators for...
Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: a cost-effectiveness analysis using a... (Publications)
most sensitive to severity and mortality due to vivax malaria, the lifetime and number of semiquantitative G6PD analysers needed, cost per malaria episode and per G6PD test strips, and life expectancy [...] BACKGROUND: Malaria transmission modelling has demonstrated the potential impact of semiquantitative glucose-6-phosphate dehydrogenase (G6PD) testing and treatment with single-dose tafenoquine for Plasmodium [...] estimates for low transmission settings, the costs of G6PD screening, and the...
Bridging the gap from molecular surveillance to programmatic decisions for malaria control and elimination (Publications)
An increasing number of molecular and genomic assays are available to study malaria parasite populations. However, so far they have played a marginal role in informing policy and programmatic decision-making [...] the origin of imported infections and characterize transmission chains in settings with very low malaria transmission, and using serology to monitor recent and past exposures in low-transmission settings [...] integrate molecular and genomic data into control program decision-making,...
Relative effects of climate factors and malaria control interventions on changes of parasitaemia risk in Burkina Faso from 2014 to 2017/2018 (Publications)
the role of malaria control interventions and climatic factors in influencing changes in the risk of malaria parasitaemia. METHODS: Bayesian logistic geostatistical models were fitted on Malaria Indicator [...] Burkina Faso, the prevalence of malaria has decreased over the past two decades, following the scale-up of control interventions. The successful development of malaria parasites depends on several climatic [...] obtained in 2014 and 2017/2018 to estimate the effects of malaria control...