Effects of climate variability on malaria transmission in southern Côte d'Ivoire, West Africa (Publications)
variables and malaria transmission in Côte d’Ivoire. We used the VECTRI model to predict malaria transmission in southern Côte d’Ivoire. First, we tested the suitability of VECTRI in modeling malaria transmission [...] Malaria continues to be a major public health concern with a substantial burden in Africa. Even though it has been widely demonstrated that malaria transmission is climate-driven, there have been very [...] rate (EIR) from the VECTRI model was well correlated with the observed mal...
Sporozoite immunization: innovative translational science to support the fight against malaria (Publications)
'sporozoites,' 'malaria,' and 'vaccines.' EXPERT OPINION: First generation (radiation-attenuated) PfSPZ vaccines are safe, well tolerated, 80-100% efficacious against homologous controlled human malaria infection [...] INTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly [...] effective vaccine is urgently needed, especially for Plasmodium...
The troubled puberty of malaria parasites (Publications)
Sexual differentiation of malaria parasites is essential for transmission, yet the underlying mechanisms are poorly understood. Russell et al. elegantly combined a loss-of-function screen with single-cell
Empowering rural communities for effective larval source management: a small-scale field evaluation of a community-led larviciding approach to control... (Publications)
source management, particularly larviciding, is mainly implemented in urban settings to control malaria and other mosquito-borne diseases. In Tanzania, the government has recently expanded larviciding [...] characterize and target larval habitats of Anopheles funestus mosquitoes, the dominant vector of malaria transmission in south-eastern Tanzania. Methods: A mixed-methods study was used. First, intervie [...] community-based volunteers were trained to identify and characterize aquatic habitats...
Forecasting malaria dynamics based on causal relations between control interventions, climatic factors, and disease incidence in western Kenya (Publications)
drivers and investigate their effects, interaction strength, and suitability ranges on malaria incidence. Monthly malaria cases were collected at St. Elizabeth Lwak Mission Hospital. Intervention coverage [...] Short-term forecasting of malaria incidence was performed using state-space reconstruction. RESULTS: We observed causal links between climatic drivers, bed net use, and malaria incidence. LSTD lagged over [...] BACKGROUND: Malaria remains one of the deadliest diseases worldwide,...
AnophelesModel: an R package to interface mosquito bionomics, human exposure and intervention effects with models of malaria intervention impact (Publications)
semi-field studies of malaria transmission have gathered geographic-specific information about mosquito ecology, behaviour and their sensitivity to interventions. Mathematical models of malaria transmission can [...] incorporate such data to infer the likely impact of vector control interventions and hence guide malaria control strategies in various geographies. To facilitate this process and make model predictions [...] addition, it offers formatted outputs ready to use in downstream analyses...
Malaria, climate variability, and interventions: modelling transmission dynamics (Publications)
of the relative impact of climate change on malaria dynamics is a complex problem. Climate is a well-known factor that plays a crucial role in driving malaria outbreaks in epidemic transmission areas. However [...] influence in endemic environments with intensive malaria control interventions is not fully understood, mainly due to the scarcity of high-quality, long-term malaria data. The demographic surveillance systems [...] effects of weather variability on the burden of malaria. Here, using a...
Modelling the impact of interventions on imported, introduced and indigenous malaria infections in Zanzibar, Tanzania (Publications)
Malaria cases can be classified as imported, introduced or indigenous cases. The World Health Organization's definition of malaria elimination requires an area to demonstrate that no new indigenous cases [...] cases have occurred in the last three years. Here, we present a stochastic metapopulation model of malaria transmission that distinguishes between imported, introduced and indigenous cases, and can be used [...] interventions in a setting with low transmission and ongoing case importation....