Sub-lethal aquatic doses of pyriproxyfen may increase pyrethroid resistance in malaria mosquitoes (Publications)
and Anopheles species. We examined whether PPF added to larval habitats of pyrethroid-resistant malaria vectors can modulate levels of resistance among emergent adult mosquitoes. METHODOLOGY: Third-instar
Priority setting in HIV, tuberculosis, and malaria - new cost-effectiveness results from WHO-CHOICE (Publications)
cost-effectiveness of the selected interventions. Impact modelling was performed using the OpenMalaria platform for malaria and using the Goals and TIME (TB Impact Model and Estimates) models in Spectrum for HIV [...] interventions for HIV, TB and malaria were cost-effective, with cost-effectiveness ratios less than I$ 100/HLY saved for virtually all interventions included. HIV, TB and malaria prevention and treatment [...] the 21st century (2000-2010) with respect to allocative efficiency in...
Identification and profiling of a novel diazaspiro[3.4]octane chemical series active against multiple stages of the human malaria parasite... (Publications)
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycl
Real-time dispersal of malaria vectors in rural Africa monitored with lidar (Publications)
observation of mosquito behavior with high spatio-temporal resolution limits progress towards improved malaria vector control. We deployed a high-resolution entomological lidar to monitor a half-kilometer static [...] this study demonstrate how lidar-based monitoring could dramatically improve our understanding of malaria vector ecology and control options.
Human behavior, livelihood, and malaria transmission in two sites of Papua New Guinea (Publications)
BACKGROUND: Malaria transmission is currently resurging in Papua New Guinea (PNG). In addition to intervention coverage, social and cultural factors influence changes in epidemiology of malaria in PNG. This [...] in relation to current malaria control efforts. METHODS: A mixed-method design was used in 2 sites in PNG. In-depth interviews, focus group discussions, cross-sectional malaria indicator survey, and population [...] d in adult men. CONCLUSIONS: Our findings highlight the potential of...
New methodological approaches to monitor long lasting insecticidal nets (LLINs) durability for sustained malaria control (Publications)
Long lasting insecticidal nets (LLINs) are the current primary vector control measure to prevent malaria transmission. They function by inhibiting mosquitoes from blood feeding and also killing mosquitoes [...] Resistance) and 2) Holed Net project. The ABCDR project aimed at understanding of bednet durability in malaria endemic countries and factors affecting bednet durability with the main focus of using that information
Mining Sudanese medicinal plants for natural compounds against malaria and neglected tropical diseases (Publications)
Tropical parasitic diseases such as malaria, human African trypanosomiasis, Chagas disease, mycetoma, and leishmaniasis affect more than a billion people worldwide and have devastating consequences. There
Longitudinal study based on a safety registry for malaria patients treated with artenimol-piperaquine in six European countries (Publications)
BACKGROUND: European travellers to endemic countries are at risk of malaria and may be affected by a different range of co-morbidities than natives of endemic regions. The safety profile, especially cardiac [...] isinin)-piperaquine (APQ) Eurartesim((R)) during treatment of uncomplicated imported falciparum malaria is not adequately described due to the lack of longitudinal studies in this population. The present [...] 255/257 (99.2%). CONCLUSIONS: APQ appears as an effective and well-tolerated...
Christian Lengeler: Malaria breitet sich wieder aus [Radio Broadcast] (Publications)
Das Ziel der Weltgesundheitsorganisation: Malaria bis 2050 auszurotten. Noch immer sterben rund eine halbe Million Menschen jährlich an Malaria, die Zahl der Toten sinkt seit einigen Jahren nicht mehr
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies (Publications)
Some Plasmodium falciparum repetitive interspersed families of polypeptides (RIFINs)—variant surface antigens that are expressed on infected erythrocytes1—bind to the inhibitory receptor LAIR1, and in