Inter-sectoral approaches for the prevention and control of malaria among the mobile and migrant populations: a scoping review (Publications)
knowledge about malaria, initiation and promotion of bed nets utilization, increased access to diagnosis and treatment in a surveillance context and contributed towards a reduction in malaria transmission [...] with correct knowledge about malaria transmission (70%, 95% CI 57-83%). Interventions targeting the use of bed nets utilization were two times more likely to reduce malaria incidence amongst the targeted [...] BACKGROUND: Malaria cases among mobile and migrant populations (MMPs) represent...
Spatial-temporal heterogeneity in malaria receptivity is best estimated by vector biting rates in areas nearing elimination (Publications)
when vector control can be withdrawn after malaria is eliminated depend on the receptivity or potential of an area to support vector populations. To guide malaria control and elimination programmes, the potential [...] estimate malaria receptivity and transmission were compared within and among geographically localised villages of active transmission in the Western Province of the Solomon Islands. RESULTS: Malaria transmission [...] inoculation and parity rates could not be measured with the...
Diagnostic performance of conventional and ultrasensitive rapid diagnostic tests for malaria in febrile outpatients in Tanzania (Publications)
Background: A novel ultra-sensitive malaria RDT (us-RDT) has been developed for improved active P.falciparum case detection. The utility of this us-RDT in clinical diagnosis and fever management has not [...] infections. Conclusion: There is neither gain nor risk to apply us-RDT rather than co-RDT for clinical malaria diagnosis. In febrile patients, only a small proportion of infections are characterized by parasite
The promise, problems and pitfalls of mass drug administration for malaria elimination: a qualitative study with scientists and policymakers (Publications)
mass drug administration (MDA). This article explores attitudes towards and perceptions of MDA for malaria elimination among policymakers and leading malariologists. Methods: Thirty-two semistructured interviews [...] with policymakers (n=17) and principal investigators (n=15) selected based on their involvement in malaria prevention, control and elimination in the GMS. Interviews were audio recorded and transcribed for [...] Results: Researchers and policymakers described reluctance and...
Insecticide-treated nets for preventing malaria (Publications)
severe malaria episodes. Insecticide-treated nets have since become a core intervention for malaria control and have contributed greatly to the dramatic decline in disease incidence and malaria-related [...] to estimate the impact of ITNs on malaria transmission today. OBJECTIVES: The primary objective of this review was to assess the impact of ITNs on mortality and malaria morbidity, incorporating any evidence [...] falciparum malaria by 17% compared to no nets (RR 0.83, 95% CI 0.71 to 0.98; 6...
Investigating sulfoxide-to-sulfone conversion as a prodrug strategy for a phosphatidylinositol 4-kinas inhibitor in a humanized mouse model of malaria (Publications)
its corresponding sulfone metabolite, were evaluated in the NOD-scid IL2Rgamma(null) (NSG) murine malaria disease model of Plasmodium falciparum infection. We hypothesized that the sulfoxide would serve [...] dosed, thereby demonstrating that the sulfoxide served as an effective prodrug for the treatment of malaria.
Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria in Papua New Guinea (Publications)
dihydroartemisinin-piperaquine (DHA-PPQ) as the first- and second-line treatments for uncomplicated malaria, respectively. This study was conducted to assess the efficacy of both drugs following adoption of [...] CONCLUSIONS: AL and DHA-PPQ were efficacious as first- and second-line treatments for uncomplicated malaria in PNG. Continued in vivo efficacy monitoring is warranted considering the threat of resistance to
Community-based prevalence of typhoid fever, typhus, brucellosis and malaria among symptomatic individuals in Afar Region, Ethiopia (Publications)
650 suspected individuals for malaria, 16 (2.5%) were found positive for P. falciparum infection. CONCLUSION: In this study, typhoid fever, typhus, brucellosis and malaria were observed among symptomatic [...] scarcity of proper diagnostic tools, febrile illness related symptoms are often misdiagnosed as malaria. Information on causative agents of febrile illness related symptoms among pastoral communities in [...] based cross-sectional survey, we assessed the prevalence of typhoid fever,...
