On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity (Publications)
known as MMV1557817, and show that it targets multiple stages of the malaria parasite lifecycle, is active in a preliminary mouse malaria model, and has a novel mechanism of action. Excitingly, resistance [...] To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor [...] digestion in asexual parasites. MMV1557817 can kill sexual-stage P....
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity (Publications)
known as MMV1557817, and show that it targets multiple stages of the malaria parasite lifecycle, is active in a preliminary mouse malaria model, and has a novel mechanism of action. Excitingly, resistance [...] To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor [...] digestion in asexual parasites. MMV1557817 can kill sexual-stage P....
Repeated mass distributions and continuous distribution of long-lasting insecticidal nets: modelling sustainability of health benefits from mosquito... (Publications)
LLIN distribution were also examined. METHODS: Dynamic simulations of malaria in humans and mosquitoes were run on the OpenMalaria platform, using stochastic individual-based simulation models. LLINs were [...] BACKGROUND: Stagnating funds for malaria control have spurred interest in the question of how to sustain the gains of recent successes with long-lasting insecticidal nets (LLINs) and improved case management [...] management (CM). This simulation study examined the malaria transmission...
PfSPZ Vaccine induces focused humoral immune response in HIV positive and negative Tanzanian adults (Publications)
stage malaria vaccine candidate based on whole, radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), has proven safe and effective in mediating sterile protection from malaria in malaria-naïve [...] underexplored, target for vaccine-induced antibodies in malaria pre-exposed volunteers. FUNDING: This work was supported by the Equatorial Guinea Malaria Vaccine Initiative (EGMVI), the Clinical Trial Platform [...] , we profiled IgG and IgM responses to PfSPZ Vaccine and subsequent...
Repeated mass distributions and continuous distribution of long-lasting insecticidal nets: modelling sustainability of health benefits from mosquito... (Publications)
LLIN distribution were also examined. METHODS: Dynamic simulations of malaria in humans and mosquitoes were run on the OpenMalaria platform, using stochastic individual-based simulation models. LLINs were [...] BACKGROUND: Stagnating funds for malaria control have spurred interest in the question of how to sustain the gains of recent successes with long-lasting insecticidal nets (LLINs) and improved case management [...] management (CM). This simulation study examined the malaria transmission...
Creating an "enabling environment" for taking insecticide treated nets to national scale: the Tanzanian experience (Publications)
of its population at high risk of malaria by 2005. The country is, therefore, determined to ensure that sustainable malaria control using insecticide-treated nets is carried out on a national scale. CASE [...] INTRODUCTION: Malaria is the largest cause of health services attendance, hospital admissions and child deaths in Tanzania. At the Abuja Summit in April 2000 Tanzania committed itself to protect 60% of [...] been involved for two decades in the research process for developing...
Creating an "enabling environment" for taking insecticide treated nets to national scale: the Tanzanian experience (Publications)
of its population at high risk of malaria by 2005. The country is, therefore, determined to ensure that sustainable malaria control using insecticide-treated nets is carried out on a national scale. CASE [...] INTRODUCTION: Malaria is the largest cause of health services attendance, hospital admissions and child deaths in Tanzania. At the Abuja Summit in April 2000 Tanzania committed itself to protect 60% of [...] been involved for two decades in the research process for developing...
Distribution of survival times of deliberate <em>Plasmodium falciparum</em> infections in tertiary syphilis patients (Publications)
has important implications for mathematical modelling of malaria, which has for the past century exclusively assumed that the duration of malaria infections has an exponential distribution. It is desirable [...] influences the length of monitoring needed in an intervention programme for eliminating or reducing malaria
Distribution of survival times of deliberate <em>Plasmodium falciparum</em> infections in tertiary syphilis patients (Publications)
has important implications for mathematical modelling of malaria, which has for the past century exclusively assumed that the duration of malaria infections has an exponential distribution. It is desirable [...] influences the length of monitoring needed in an intervention programme for eliminating or reducing malaria
Disruption of erythrocyte rosettes and agglutination of erythrocytes infected with<em> Plasmodium falciparum</em> by the sera of Papua New Guineans (Publications)
Antibodies disrupting erythrocyte rosettes have been associated with protection against cerebral malaria, and antibodies agglutinating infected erythrocytes with reduced episodes of clinical disease. We [...] have studied the capacity of serum from Papua New Guinean adults and children with a spectrum of malaria exposure, including children and adults at the time of clinical disease, to disrupt erythrocyte rosettes [...] Rosette disrupting antibodies were equally frequent in children with...