Comparison of a new IgG-EIA for the detection of anti-plasmodium antibodies with two currently used assays (Publications)
Material and Methods: In the present study two routine Plasmodium spp. ELISA (CAPTIA™ Malaria EIA, Trinity Biotech, and Malaria EIA, Bio-Rad) were compared with a new commercial ELISA (ELISA IgG, EUROIMMUN). [...] Conclusion: The comparison of the new EUROIMMUN ELISA and the established CAPTIA™ Malaria EIA (Trinity Biotech) and Ma-laria EIA (BioRad) used for routine blood donor screening in two laboratory blood donation [...] Background: Malaria is a mosquito-borne infectious disease caused by...
Mechanistic within-host models of the asexual <em>Plasmodium falciparum</em> infection: a review and analytical assessment (Publications)
the last 30 years, several mechanistic mathematical models of malaria parasite within-host dynamics have been published and used in malaria transmission models. METHODS: Mechanistic within-host models of [...] and inter-individual variability. RESULTS: The assessed within-host malaria models generally replicate infection dynamics in malaria-naive individuals. However, there are substantial differences between [...] BACKGROUND: Malaria blood-stage infection length and intensity are important...
Comparison of a new IgG-EIA for the detection of anti-plasmodium antibodies with two currently used assays (Publications)
Material and Methods: In the present study two routine Plasmodium spp. ELISA (CAPTIA™ Malaria EIA, Trinity Biotech, and Malaria EIA, Bio-Rad) were compared with a new commercial ELISA (ELISA IgG, EUROIMMUN). [...] Conclusion: The comparison of the new EUROIMMUN ELISA and the established CAPTIA™ Malaria EIA (Trinity Biotech) and Ma-laria EIA (BioRad) used for routine blood donor screening in two laboratory blood donation [...] Background: Malaria is a mosquito-borne infectious disease caused by...
Mechanistic within-host models of the asexual <em>Plasmodium falciparum</em> infection: a review and analytical assessment (Publications)
the last 30 years, several mechanistic mathematical models of malaria parasite within-host dynamics have been published and used in malaria transmission models. METHODS: Mechanistic within-host models of [...] and inter-individual variability. RESULTS: The assessed within-host malaria models generally replicate infection dynamics in malaria-naive individuals. However, there are substantial differences between [...] BACKGROUND: Malaria blood-stage infection length and intensity are important...
The treatment of non-malarial febrile illness in Papua New Guinea: findings from cross sectional and longitudinal studies of health worker practice (Publications)
recently shifted from a presumptive to a 'test and treat' malaria case management policy. This shift was supported by the widespread introduction of malaria rapid diagnostic tests in health facilities across [...] detailing how to conduct and interpret a malaria rapid diagnostic test and how to treat test positive cases; however, little instruction on treating non-malaria febrile cases was provided. Accordingly, [...] l febrile patients in the 12-month period immediately following the...
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment and prevention of disease transmission (Publications)
Renewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life-cycle. We have previously reported the [...] that have activity in the prevention and treatment of blood stage infection in a mouse model of malaria. Consistent with the activity profile of this series the clinical candidate KAF156 shows blood s [...] drug-sensitive and drug-resistant strains as well as potent therapeutic activity in...
Contribution of dengue fever to the burden of acute febrile illnesses in Papua New Guinea: an age-specific prospective study (Publications)
were enrolled, and 317 patients with a negative rapid diagnostic test (RDT) for malaria were tested for dengue. Malaria was confirmed in 52% (301/578, 95% confidence interval [CI] = 48-56%), DF was diagnosed [...] Abstract. Malaria is a major contributor to the burden of febrile illnesses in Papua New Guinea (PNG). Dengue fever (DF) is likely to contribute; however, its epidemiology in PNG is poorly understood. [...] diagnosed in 8% (46/578, 95% CI = 6-10%), and 40% (95% CI = 36-44%) had neither...
Contribution of dengue fever to the burden of acute febrile illnesses in Papua New Guinea: an age-specific prospective study (Publications)
were enrolled, and 317 patients with a negative rapid diagnostic test (RDT) for malaria were tested for dengue. Malaria was confirmed in 52% (301/578, 95% confidence interval [CI] = 48-56%), DF was diagnosed [...] Abstract. Malaria is a major contributor to the burden of febrile illnesses in Papua New Guinea (PNG). Dengue fever (DF) is likely to contribute; however, its epidemiology in PNG is poorly understood. [...] diagnosed in 8% (46/578, 95% CI = 6-10%), and 40% (95% CI = 36-44%) had neither...
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment and prevention of disease transmission (Publications)
Renewed global efforts toward malaria eradication have highlighted the need for novel antimalarial agents with activity against multiple stages of the parasite life-cycle. We have previously reported the [...] that have activity in the prevention and treatment of blood stage infection in a mouse model of malaria. Consistent with the activity profile of this series the clinical candidate KAF156 shows blood s [...] drug-sensitive and drug-resistant strains as well as potent therapeutic activity in...
The use of the polymerase chain reaction for more sensitive detection of <em>Plasmodium falciparum</em> (Publications)
positive for P. vivax and P. malariae an underlying P. falciparum infection remained undetected by microscopy. The introduction of PCR has opened up new possibilities in malaria diagnosis and research. [...] The prevalence of Plasmodium falciparum in children and adults living in a malaria-endemic area in Papua New Guinea was determined by microscopy and by polymerase chain reaction (PCR). The sensitivity