Contrasting genomic epidemiology between sympatric <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> populations (Publications)
The malaria parasites Plasmodium falciparum and Plasmodium vivax differ in key biological processes and associated clinical effects, but consequences on population-level transmission dynamics are difficult [...] difficult to predict. This co-endemic malaria study from Guyana details important epidemiological contrasts between the species by coupling population genomics (1396 spatiotemporally matched parasite genomes [...] uniquely to selected demographics. We discuss possible underlying...
Ecohealth approach to urban waste management: exposure to environmental pollutants and health risks in Yamoussoukro, Côte d'Ivoire (Publications)
standards of surface water quality. Questionnaire results showed that malaria was the most commonly reported disease. Diarrhoea and malaria were associated with poor sanitation. Households having dry latrines [...] confidence interval (CI) 1.2-2.7) compared to latrines with septic tanks and also a higher risk for malaria (OR = 1.9, 95% (CI) 1.1-3.3). Our research showed that combining health and environmental assessments
Semi-field evaluation of a volatile transfluthrin-based intervention reveals efficacy as a spatial repellent and evidence of other modes of action (Publications)
Presently, the most common malaria control tools-i.e., long lasting insecticide-treated nets (LLINs) and indoor residual spraying (IRS)-are limited to targeting indoor biting and resting behaviors of Anopheles [...] Anopheles mosquito species. Few interventions are targeted towards malaria control in areas where transmission is driven or persists due to outdoor biting behaviors. This study investigated a volatile [...] Southern Province, Zambia, is one such environment where outdoor biting is...
Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection (Publications)
lower clinical malaria incidence after adjusting for age group, site and post-vaccination anti-CSP levels. RTS,S/AS01E-induced IgG may bind strongly not only to CSP, but to unrelated malaria antigens, and [...] and this seems to either confer, or at least be a marker of, increased protection from clinical malaria.
Case report: Diagnostic challenges in the detection of a mixed <em>Plasmodium vivax/ovale</em> infection in a non-endemic setting (Publications)
In clinical practice, mixed-species malaria infections are often not detected by light microscopy (LM) or rapid diagnostic test, as a low number of parasites of one species may occur. Here, we report the [...] This case demonstrates the significance of molecular testing in the detection of mixed-species malaria infections and highlights the importance of a detailed data analysis during the medical validation
Spatial epidemiology of urban health risks in select West African cities (Publications)
epidemiology of diarrhaea and malaria, and their associated risks factors in the following select West African cities. Spatial variability of exposure to diarrhaea and malaria transmission is linked to several
Case report: Diagnostic challenges in the detection of a mixed <em>Plasmodium vivax/ovale</em> infection in a non-endemic setting (Publications)
In clinical practice, mixed-species malaria infections are often not detected by light microscopy (LM) or rapid diagnostic test, as a low number of parasites of one species may occur. Here, we report the [...] This case demonstrates the significance of molecular testing in the detection of mixed-species malaria infections and highlights the importance of a detailed data analysis during the medical validation
Spatial epidemiology of urban health risks in select West African cities (Publications)
epidemiology of diarrhaea and malaria, and their associated risks factors in the following select West African cities. Spatial variability of exposure to diarrhaea and malaria transmission is linked to several
Mathematical Epidemiology (Page)
https://www.swisstph.ch/en/about/eph/disease-modelling/mathematical-epidemiology
Correction: Testing and treatment for malaria elimination: a systematic review. Malar J . 2024;23:63. DOI: 10.1186/s12936-024-04861-x Related Topics Health Interventions Malaria Helminths Human African Trypanosomiasis [...] computational models to improve understanding of population, infection and disease dynamics, focusing on malaria and neglected tropical diseases. Nakul Chitnis PhD, PD Dr. Group Leader +41612848242 nakul.chitn [...] Hofer Lars Kamber Alexis Martin Louis Perriens Taru Singhal...
Probing <em>Plasmodium falciparum</em> sexual commitment at the single-cell level (Publications)
Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure. Here we apply single cell transcriptomics to unravel [...] programs, with important implications for our understanding of parasite biology and the ongoing malaria elimination campaign.