Pharmacophore model for pentamidine analogs active against <em>Plasmodium falciparum</em> (Publications)
to be active against Plasmodium falciparum, which causes the most dangerous malarial infection. Malaria is a widespread disease known to affect hundreds of millions of people and presents a perceivable [...] polar oxygen and amidine substituents and the hydrophobic linking chain for the activity against malaria
Synthesis and pharmacological evaluation of fluorescent and photoactivatable analogues of antiplasmodial naphthylisoquinolines (Publications)
antiplasmodial activities in vitro and in vivo, even against chloroquine-resistant strains of the malaria pathogen. For the directed optimization of these activities, an investigation of the mode of action [...] their pharmacological potential as a valuable lead structure against the widespread tropical disease malaria
Pharmacophore model for pentamidine analogs active against <em>Plasmodium falciparum</em> (Publications)
to be active against Plasmodium falciparum, which causes the most dangerous malarial infection. Malaria is a widespread disease known to affect hundreds of millions of people and presents a perceivable [...] polar oxygen and amidine substituents and the hydrophobic linking chain for the activity against malaria
Use of antibiotics within the IMCI guidelines in outpatient settings in Papua New Guinean children: an observational and effectiveness study (Publications)
routine outpatient clinics. METHODS: Making use of a passive case detection system established for a malaria prevention trial in outpatient clinics in Papua New Guinea, the appropriateness and effectiveness [...] antibiotics and re-attendances within 14 days for mild pneumonia, mild diarrhoea and uncomplicated malaria whether they were managed with or without antibiotics (proxy of effectiveness). Appropriateness was
Probing <em>Plasmodium falciparum</em> sexual commitment at the single-cell level (Publications)
Background: Malaria parasites go through major transitions during their complex life cycle, yet the underlying differentiation pathways remain obscure. Here we apply single cell transcriptomics to unravel [...] programs, with important implications for our understanding of parasite biology and the ongoing malaria elimination campaign.
WHO antimalarial trial guidelines: good science, bad news? (Publications)
infections arising during the several-week follow-up period in drug trials. Genetic profiling of malaria infections can guide this decision but is notoriously difficult in practice. Previous World Health [...] more accurate but will likely rise twofold due to better detection of treatment failures, and the malaria community needs to anticipate and prepare for potentially large increases in estimated failure rates
Assessing whether universal coverage with insecticide-treated nets has been achieved: is the right indicator being used? (Publications)
(ITNs) are the primary tool for malaria vector control in sub-Saharan Africa, and have been responsible for an estimated two-thirds of the reduction in the global burden of malaria in recent years. While the [...] ITN for 2 people did not exceed 60% at the national level in any survey, except in Uganda's 2014 Malaria Indicator Survey (MIS). At 80% population ITN access, the expected proportion of households with [...] success of an ITN distribution programme. Under current ITN distribution...
Association between the proportion of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infections detected by passive surveillance and the... (Publications)
proportion of infections detected in routine malaria data, P(Detect), was derived from paired household cross-sectional survey and routinely collected malaria data within health facilities. P(Detect) was [...] BACKGROUND: Passively collected malaria case data are the foundation for public health decision making. However, because of population-level immunity, infections might not always be sufficiently symptomatic [...] model in 431 clusters spanning the Americas, Africa, and Asia. The...
Lack of associations of alpha(+) - thalassemia with the risk of <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> infection and disease in... (Publications)
unknown. An increase in risk of Plasmodium vivax malaria in early childhood resulting in a cross-species protection against severe P. falciparum malaria has been proposed as a possible mechanism in Melanesian [...] wild-type allele. No significant differences in the incidence of P. falciparum (Pf) or P. vivax (Pv) malaria were observed between alpha(+)-thalassemia homozygote (Pf: Incidence rate ratio (IRR) = 1.13, CI(95) [...] = 0.008). This study therefore failed to confirm an increased risk of...
Ultra-sensitive detection of <em>Plasmodium falciparum</em> by amplification of multi-copy subtelomeric targets (Publications)
qPCR in community surveillance and for monitoring interventions to better describe malaria epidemiology and inform malaria elimination efforts [...] BACKGROUND: Planning and evaluating malaria control strategies relies on accurate definition of parasite prevalence in the population. A large proportion of asymptomatic parasite infections can only be [...] might still remain undetected when absent in the limited blood volume sampled. CONCLUSIONS: Measured malaria prevalence in communities is...
