<em>Plasmodium falciparum</em> merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic... (Publications)
allelic families of Plasmodium falciparum merozoite surface proteins 2 are considered promising malaria vaccine candidates. The aim of the current study is to characterize the immune response (epitope [...] (epitope mapping) in naturally exposed individuals and relate immune responses to the risk of clinical malaria. METHODS: To optimize their construction, the fine specificity of human serum antibodies from donors [...] response to individual epitopes within the 3D7 family-specific region...
Evaluation of anopheline diversity and abundance across outdoor collection schemes utilizing cdc light traps in Nchelenge District, Zambia (Publications)
In the global fight against malaria, standard vector control methods such as indoor residual spraying (IRS) and insecticide-treated nets (ITNs) are intended to protect inside residential structures and [...] may be exposed to outdoors. Nchelenge District in northern Zambia experiences persistently high malaria transmission even with ITNs and IRS in place. However, very few studies have examined outdoor vector [...] including a number of infectious An. funestus, may partially explain the...
Clonal expansion of artemisinin-resistant <em>Plasmodium falciparum</em> in Uganda is associated with substandard treatment practices (Publications)
the frame of the Community Access to Rectal Artesunate for Malaria project, blood samples were collected from children with signs of severe malaria before and after RAS implementation. K13 polymorphisms were [...] a driver of this recent emergence. Rectal artesunate (RAS) as pre-referral treatment for severe malaria in children was implemented in 2019 in Northern Uganda. The objective of this study was to determine
Infection Biology and Molecular Epidemiology | Swiss TPH (Page)
https://www.swisstph.ch/en/infection-biology-and-molecular-epidemiology
infectious diseases. In the field of the life sciences, Swiss TPH places particular emphasis on malaria, tuberculosis and other poverty-related infectious diseases. We utilise state-of-the-art basic research [...] of new drugs, diagnostics and vaccines. Helminths HIV/AIDS Human African Trypanosomiasis (HAT) Malaria Neglected Tropical Diseases (NTDs) Tuberculosis
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite Plasmodium falciparum (PfdUTPase)
Delayed anemia after treatment with injectable artesunate in the democratic republic of the Congo: a manageable issue (Publications)
treatment of severe malaria. A total of 350 patients (215 [61.4%] < 5 years of age and 135 [38.6%] > /= 5 years of age) were followed-up after treatment with injectable artesunate for severe malaria in hospitals
The epidemiology of multiple <em>Plasmodium falciparum</em> infections. 7. Dynamics of multiple <em>Plasmodium falciparum </em>infections in infants... (Publications)
The force of infection and recovery rate for malaria in infants in a highly endemic area of Tanzania were analysed using polymerase chain reaction-restriction fragment length polymorphism genotyping of [...] recovery rates were in children under 4 months of age. The higher susceptibility of infants to clinical malaria in comparison with older children, in areas of very high transmission, may be largely a consequence
Trisubstituted pyrimidines as efficacious and fast-acting antimalarials (Publications)
mouse model of malaria. The most promising compound (13) showed a reduction in parasitemia of 96% when dosed at 30 mg/kg orally once a day for 4 days in the P. berghei mouse model of malaria. It also demonstrated
New algorithm for managing childhood illness using mobile technology (ALMANACH): a controlled non-inferiority study on clinical outcome and antibiotic... (Publications)
INTRODUCTION: The decline of malaria and scale-up of rapid diagnostic tests calls for a revision of IMCI. A new algorithm (ALMANACH) running on mobile technology was developed based on the latest evidence [...] (387%) in control arm were diagnosed with an infection in need for antibiotic, while 38% and 96% had malaria. 815/838 (973%;961-98.4%) were cured at D7 using ALMANACH versus 573/623 (920%;898-941%) using standard
dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors (Publications)
route for therapeutic intervention against malaria. Here we report inhibition and structural studies on the deoxyuridine nucleotidohydrolase from the malaria parasite Plasmodium falciparum (PfdUTPase)