Infection and co-infection with helminths and <em>Plasmodium</em> among school children in Côte d'Ivoire: results from a national cross-sectional... (Publications)
Helminth infection and malaria remain major causes of ill-health in the tropics and subtropics. There are several shared risk factors (e.g., poverty), and hence, helminth infection and malaria overlap geographically [...] provide a rationale to combine control interventions that simultaneously aim at helminthiases and malaria
Surveillance of molecular markers of <em>Plasmodium falciparum</em> artemisinin resistance (<em>kelch</em>13 mutations) in Papua New Guinea between... (Publications)
Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) is a global threat to malaria control and elimination efforts. Mutations in the P. falciparum kelch13 gene (Pfk13) that are associated [...] in other parts of PNG is unknown. We investigated the prevalence of Pfk13 mutations in multiple malaria-endemic regions of PNG. P. falciparum isolates (n = 1152) collected between 2016 and 2018 and assessed [...] Continued surveillance for molecular markers of drug resistance is...
On a mission to block transmission (Publications)
falciparum parasites could provide a platform to evaluate new drugs and vaccines aimed at blocking malaria transmission.
On a mission to block transmission (Publications)
falciparum parasites could provide a platform to evaluate new drugs and vaccines aimed at blocking malaria transmission.
Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the plasmodium life cycle (Publications)
Quinolines are excellent ligands for metal coordination and are deployed as drugs for malaria treatment. There is a growing body of evidence indicating that metal complexes can be conjugated with antimalarial [...] findings indicate that metal coordination is a potential chemical tool for drug design and discovery in malaria.
Structure-activity relationships and antiplasmodial potencies of novel 3,4-disubstituted 1,2,5-oxadiazoles (Publications)
The 4-substituted 3-amino-1,2,5-oxadiazole 1 from the Malaria Box Project of the Medicines for Malaria Venture foundation shows very promising selectivity and in vitro activity against Plasmodium falciparum
A simple and efficient tool for trapping gravid <em>Anopheles</em> at breeding sites (Publications)
BACKGROUND: No effective tool currently exists for trapping ovipositing malaria vectors. This creates a gap in our ability to investigate the behavior and ecology of gravid Anopheles. FINDINGS: Here we [...] ecology of gravid female Anophelines. It strongly implies that at least two of the major vectors of malaria in Africa land on the water surface during the oviposition process, and demonstrates that Anophelines
Activities of quinoxaline, nitroquinoxaline and [1,2,4]triazolo[4,3-a]quinoxaline analogs of MMV007204 against <em>Schistosoma mansoni</em> (Publications)
Recently, an antimalarial quinoxaline derivative (MMV007204) from the Medicines for Malaria Venture (MMV) Malaria Box demonstrated promise against Schistosoma mansoni In this study, 47 synthesized compounds
The catalytic subunit of <em>Plasmodium falciparum</em> casein kinase 2 is essential for gametocytogenesis (Publications)
pleiotropic kinase phosphorylating substrates in different cellular compartments in eukaryotes. In the malaria parasite Plasmodium falciparum, PfCK2 is vital for asexual proliferation of blood-stage parasites [...] PfCK2alpha catalytic subunit in gametocytes, the sexual forms of the parasite that are essential for malaria transmission. We show that PfCK2alpha localizes to the nucleus and cytoplasm in asexual and sexual
Multiplexed ddPCR-amplicon sequencing reveals isolated <em>Plasmodium falciparum</em> populations amenable to local elimination in Zanzibar, Tanzania (Publications)
Zanzibar has made significant progress toward malaria elimination, but recent stagnation requires novel approaches. We developed a highly multiplexed droplet digital PCR (ddPCR)-based amplicon sequencing [...] genetic structure across the Zanzibar archipelago and provides actionable insights for prioritizing malaria elimination efforts.