Multiplicity and diversity of <em>Plasmodium vivax</em> infections in a highly endemic region in Papua New Guinea (Publications)
is highly endemic in the lowlands of Papua New Guinea and accounts for a large proportion of the malaria cases in children less than 5 years of age. We collected 2117 blood samples at 2-monthly intervals [...] age (P = 0.02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and
Epidemiology of multiple <em>Plasmodium falciparum</em> infections. 6. Multiple <em>Plasmodium falciparum</em> infections in Tanzanian infants (Publications)
clinical malaria, in contrast to the situation in older children (> 2 years). The findings help in the understanding of infection dynamics, premunition, and development of semi-immunity in malaria.
Field-caught permethrin-resistant <em>Anopheles gambiae</em> overexpress CYP6P3, a P450 that metabolises pyrethroids (Publications)
Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is receiving increasing attention because it threatens the sustainability of malaria vector control programs in sub-Saharan Africa
2,8-disubstituted-1,5-naphthyridines as dual inhibitors of <em>Plasmodium falciparum</em> phosphatidylinositol-4-kinase and hemozoin formation with... (Publications)
isolates and lab-raised drug-resistant strains of Pf. It was efficacious in the humanized NSG mouse malaria infection model at a single oral dose of 32 mg/kg. This compound was nonteratogenic in the zebrafish [...] human dose, indicating that this series has the potential to deliver a preclinical candidate for malaria.
Expert Committee Memberships | Scientific and Policy Advice (Page)
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Partnership to End Malaria (Coordinator) Multi Sectoral Action Working Group, RBM Partnership to End Malaria (Coordinator) Vector Control Working Group, RBM Partnership to End Malaria (Coordinator) Christian [...] Institute of Medical Research (BC) Fakultätsversammlung Phil Nat Uni Basel WHO Malaria Policy Advisory Committee (MPAG) Zanzibar Malaria Elimination Advisory Committee Jennifer Keiser WHO Advisory Group on So [...] international organisations such as the WHO on evidence-based health...
Proteomic analysis of exported chaperone/co-chaperone complexes of <em>P. falciparum</em> reveals an array of complex protein-protein interactions (Publications)
Malaria parasites modify their human host cell, the mature erythrocyte. This modification is mediated by a large number of parasite proteins that are exported to the host cell, and is also the underlying [...] underlying cause for the pathology caused by malaria infection. Amongst these proteins are many Hsp40 co-chaperones, and a single Hsp70. These proteins have been implicated in several processes in the host cell
Combining synthetic human odours and low-cost electrocuting grids to attract and kill outdoor-biting mosquitoes: field and semi-field evaluation of an... (Publications)
BACKGROUND: On-going malaria transmission is increasingly mediated by outdoor-biting vectors, especially where indoor insecticidal interventions such as long-lasting insecticide treated nets (LLINs) are [...] dusk and dawn. MLBs fitted with one, two or three electrocuting grids were compared outdoors in a malaria endemic village in Tanzania, where vectors had lost susceptibility to pyrethroids. MLBs with three
In vitro antiprotozoal activities and cytotoxicity of some selected Cameroonian medicinal plants (Publications)
Eight extracts from seven selected Cameroonian medicinal plants, traditionally used to treat malaria and other protozoal diseases, were tested in vitro for their antiprotozoal activities against Plasm [...] Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei rhodesiense, protozoa responsible for malaria, visceral leishmaniasis, Chagas disease and African trypanosomiasis, respectively. The most active
Cytotoxic T lymphocyte (CTL) low-responsiveness to the <em>Plasmodium falciparum</em> circumsporozoite protein in naturally-exposed endemic... (Publications)
epitope(s) within the circumsporozoite (CS) protein of malaria sporozoites have been shown to play an important role in protective immunity against malaria, at least in murine models. Their role in sporozoite
Health & demographic surveillance system profile: the Taabo Health and Demographic Surveillance System, Côte d'Ivoire (Publications)
ed diseases such as schistosomiasis and malaria. The Taabo HDSS has generated setting-specific evidence on the impact of targeted interventions against malaria, schistosomiasis and other neglected tropical
