Clinical trials in low-resource settings: the perspectives of caregivers of paediatric participants from Uganda, Tanzania and Kenya (Publications)
study investigates the experience of caregivers consenting on behalf of paediatric participants in a malaria vaccine clinical trial where participation enables access to free, high-quality medical care. METHODS: [...] interviewed a total of 78 caregivers of paediatric participants previously enrolled in a phase II or III malaria vaccine clinical trial in Uganda, Tanzania and Kenya. Interviews were qualitative and analysed using
Detection of <em>Plasmodium falciparum</em> infected <em>Anopheles gambiae</em> using near‑infrared spectroscopy (Publications)
demonstrates proof-of-concept that NIRS is capable of rapidly identifying laboratory strains of human malaria infection in African mosquito vectors. CONCLUSIONS: Accurate, low-cost, reagent-free screening of [...] by NIRS could revolutionize surveillance and elimination strategies for the most important human malaria parasite in its primary African vector species. Further research is needed to evaluate how the method
Care seeking and treatment of febrile children with and without danger signs of severe disease in northern Uganda: results from three household... (Publications)
(danger signs) in rural communities are crucial for preventing complications and death from severe malaria, pneumonia, and diarrhea. We set out to determine the treatment-seeking practices and treatment patterns [...] of age with an acute febrile illness, with or without danger signs of severe disease, in a highly malaria-endemic area of northern Uganda. Three household surveys were conducted from November through December
A worldwide map of <em>Plasmodium falciparum</em> K13-propeller polymorphisms (Publications)
BACKGROUND: Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. [...] analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic. Most of the samples (84.5%) were obtained from patients who were treated at sentinel
Molecular epidemiology of <em>Plasmodium falciparum</em> infections among asymptomatic inhabitans of a holoendemic malarious area in northern Ghana (Publications)
Age dependence of malaria infection was assessed in an age-stratified cluster sample of 308 individuals from Kassena-Nankana District of northern Ghana during June and July 2000. Overall prevalence of [...] holoendemic sites in Africa, validating the use of the age-multiplicity relationship as an indicator of malaria endemicity.
Antiprotozoal activities of tetrazole-quinolines with aminopiperidine linker (Publications)
sickness) and Malaria both are insect vectored tropical diseases. Only a couple of drugs is able to cure HAT, but all of them are toxic, prone to resistance and require parenteral administration. Malaria is responsible
How many mosquito nets are needed to achieve universal coverage? Recommendations for the quantification and allocation of long-lasting insecticidal... (Publications)
Long-lasting insecticidal nets are an effective tool for malaria prevention, and "universal coverage" with such nets is increasingly the goal of national malaria control programmes. However, national level campaigns
Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to <em>Plasmodium</em> (Publications)
Current malaria therapeutics demands strategies able to selectively deliver drugs to Plasmodium-infected red blood cells (pRBCs) in order to limit the appearance of parasite resistance. Here, the poly [...] , and selective internalization into pRBCs but not in healthy erythrocytes for human and rodent malarias, may be regarded as promising candidates deserving to enter the antimalarial therapeutic arena.
Sequence and diversity of T-cell receptor alpha <em>V</em>, <em>J</em>, and <em>C</em> genes of the owl monkey <em>Aotus nancymaae</em> (Publications)
which are susceptible to infection with the human malaria parasite Plasmodium falciparum, as an animal model for the evaluation of molecularly defined malaria vaccine candidates
Clinical Trials at Swiss TPH | Bringing Science to Patients (Page)
https://www.swisstph.ch/en/services/clinical-trials
Trial for New Malaria Vaccine Malaria persists as a significant challenge in tropical and subtropical regions, prompting the initiation of the SumayaVac-1 study—a clinical trial for a new malaria vaccine known [...] and neonates weighing less than 5kg with acute malaria. The CALINA study is led by Novartis, with the scientific and financial support of Medicines for Malaria Venture (MMV), and is part of the PAMAfrica [...] capacity strengthening activities in public health and malaria, and...
