Characterization of novel antimalarial compound ACT-451840: preclinical assessment of activity and dose-efficacy modeling (Publications)
cycle stages of the human malaria parasite Plasmodium falciparum (asexual and sexual) and Plasmodium vivax (asexual) as well as oral in vivo efficacies in two murine malaria models that permit infection [...] determination of the dose-efficacy relationship of ACT-451840 under curative conditions in rodent malaria models allowed prediction of the human efficacious exposure. CONCLUSION: The dual activity of ACT-451840
Characterization of novel antimalarial compound ACT-451840: preclinical assessment of activity and dose-efficacy modeling (Publications)
cycle stages of the human malaria parasite Plasmodium falciparum (asexual and sexual) and Plasmodium vivax (asexual) as well as oral in vivo efficacies in two murine malaria models that permit infection [...] determination of the dose-efficacy relationship of ACT-451840 under curative conditions in rodent malaria models allowed prediction of the human efficacious exposure. CONCLUSION: The dual activity of ACT-451840
Synthesis of novel diazabicycles and their antiprotozoal activities (Publications)
potencies against Plasmodium falciparum K-1 and Trypanosoma b. rhodesiense, the causative organisms of malaria tropica and the East African form of sleeping sickness
Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity (Publications)
nt strain of Plasmodium falciparum, and examples 7 and 8 were active in vivo in mouse models of malaria
Ancistroheynine B and two further 7,3'-coupled naphthylisoquinoline alkaloids from<em> Ancistrocladus heyneanus</em> Wall (Publications)
c, and chiroptical methods. Biological activities of ancistroheynine B against the pathogens of malaria, leishmaniasis, Chagas' disease, and African sleeping sickness were evaluated
Ancistroheynine B and two further 7,3'-coupled naphthylisoquinoline alkaloids from<em> Ancistrocladus heyneanus</em> Wall (Publications)
c, and chiroptical methods. Biological activities of ancistroheynine B against the pathogens of malaria, leishmaniasis, Chagas' disease, and African sleeping sickness were evaluated
Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity (Publications)
nt strain of Plasmodium falciparum, and examples 7 and 8 were active in vivo in mouse models of malaria
Synthesis of novel diazabicycles and their antiprotozoal activities (Publications)
potencies against Plasmodium falciparum K-1 and Trypanosoma b. rhodesiense, the causative organisms of malaria tropica and the East African form of sleeping sickness
Improving methods for analysing anti-malarial drug efficacy trials: molecular correction based on length-polymorphic markers <em>msp</em>-1,... (Publications)
BACKGROUND: Drug efficacy trials monitor the continued efficacy of front-line drugs against falciparum malaria. Over-estimates of efficacy result in a country retaining a failing drug as first-line treatment [...] modelling to simulate parasite dynamics and genetic signals that occur in patients enrolled in malaria drug clinical trials. We compared estimates of treatment failure obtained from a selection of proposed
The three <em>Plasmodium falciparum </em>Aurora-related kinases display distinct temporal and spatial associations with mitotic structures in asexual... (Publications)
Aurora kinases are crucial regulators of mitotic cell cycle progression in eukaryotes. The protozoan malaria parasite Plasmodium falciparum replicates via schizogony, a specialised mode of cell division ch [...] throughout schizogony as well as in the non-dividing gametocyte stages, which are essential for malaria transmission. We demonstrate that all three PfARKs display distinct and highly specific and exclusive