Elimination of <em>Schistosoma mansoni</em> in infected mice by slow release of artemisone (Publications)
anti-plasmodial activity, and reduced toxicity compared to other artemisinins in clinical use against malaria. We infected adult mice by subcutaneous injection of S. mansoni cercariae (about 200) and treated [...] release of the artemisone that was verified in vivo and in vitro bioassays using drug-sensitive malaria parasites. We found superior strong anti-schistosome effects up to a total reduction of worm number
A <em>Plasmodium falciparum</em> PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface (Publications)
Uniquely among malaria parasites, Plasmodium falciparum-infected erythrocytes (iRBCs) develop membrane protrusions, known as knobs, where the parasite adhesion receptor P. falciparum erythrocyte membrane [...] formation and the associated iRBC adherence to host endothelium are directly linked to the severity of malaria and are functional manifestations of protein export from the parasite to the iRBC. A family of exported
Multiplicity of <em>Plasmodium falciparum</em> infection following intermittent preventive treatment in infants (Publications)
Intermittent preventive treatment in infants with sulphadoxine-pyrimethamine (IPTi-SP) reduces malaria morbidity by 20% to 33%. Potentially, however, this intervention may compromise the acquisition of [...] of polyclonal infections (69.6% vs. 69.7%; P = 0.99). Adjusting for study site, current and prior malaria, parasite density, and season did not change this finding. CONCLUSIONS: IPTi-SP appears to have no
Transcription profiling of a recently colonised pyrethroid resistant <em>Anopheles gambiae</em> strain from Ghana (Publications)
resistance to the pyrethroid insecticides used to treat bednets threatens the sustainability of malaria control in sub-Saharan Africa. While the impact of target site insensitivity alleles is being widely [...] detoxification--though equally important--remains elusive. The successful development of new tools for malaria intervention and management requires a comprehensive understanding of insecticide resistance, including
A 10 year study of the cause of death in children under 15 years in Manhica, Mozambique (Publications)
diseases accounted for 9.5% of the defined causes of death, and injuries for 3.9% of causes of deaths. Malaria was the single largest cause, accounting for 21.8% of cases. Pneumonia with 9.8% was the second leading [...] area. The pattern of childhood mortality in Manhica area is typical of developing countries where malaria, pneumonia and HIV/AIDS are important causes of death
First detection of N1575Y mutation in pyrethroid resistant <em>Anopheles gambiae</em> in Southern Côte d'Ivoire (Publications)
insecticide classes is widespread. In an agricultural area of Southern Cote d'Ivoire, the main malaria vector Anopheles coluzzii shows multiple resistance across insecticides mediated by both target site [...] mutation in Cote d'Ivoire, and as in other populations, it is found in both dominant West African malaria vector species. Continued monitoring of N1575Y is underway, as are studies to elucidate its contribution
New myxobacteria of the <em>Myxococcaceae</em> clade produce angiolams with antiparasitic activities (Publications)
named angiolams B, C, and D were found to display promising antiparasitic activities against the malaria pathogen Plasmodium falciparum in the 0.3-0.8 µM range.IMPORTANCEThe COVID-19 pandemic and continuously [...] diseases. However, the shortage of treatment options against protozoal parasitic infections, like malaria, is much more severe, especially for the treatment of so-called neglected tropical diseases. The
Temporal distribution of <em>Plasmodium falciparum </em>recrudescence following artemisinin-based combination therapy: an individual participant data... (Publications)
various follow-up time-points in treatment efficacy trials for uncomplicated Plasmodium falciparum malaria. METHODS: Individual patient data from 83 anti-malarial efficacy studies collated in the WorldWide [...] constructed distribution was used to estimate the optimal follow-up period for capturing a P. falciparum malaria recrudescence. Simulation studies were conducted based on the constructed distributions to quantify
An evidence synthesis approach for combining different data sources illustrated using entomological efficacy of insecticides for indoor residual... (Publications)
BACKGROUND: Prospective malaria public health interventions are initially tested for entomological impact using standardised experimental hut trials. In some cases, data are collated as aggregated counts [...] residual spray (IRS) product active ingredient, used on wall surfaces to kill mosquitoes and reduce malaria transmission, were analysed using a series of statistical models to understand the benefits and
Strategies for detection of <em>Plasmodium species</em> gametocytes (Publications)
transmission stages of malaria parasites, are determined for predicting the infectiousness of humans to mosquitoes. This measure is used for evaluating interventions that aim at reducing malaria transmission.
