Pathogens that cause acute febrile illness among children and adolescents in Burkina Faso, Madagascar and Sudan (Publications)
(11-19 years-old). Leading clinical diagnoses were respiratory tract infections [45.9% (282/615)], malaria [27.3% (168/615)], and gastrointestinal tract infections [10.7% (66/615)]. Through the TaqMan-Array [...] the most prevalent pathogen (10.2%). Overall, 69% (357/516) of patients with clinical diagnoses of malaria, respiratory, or gastrointestinal infections were prescribed a WHO-guideline-recommended empiric
Safety and protective efficacy of PfSPZ vaccine administered to HIV negative and positive Tanzanian adults (Publications)
PfSPZ Vaccine, composed of attenuated Plasmodium falciparum (Pf) sporozoites (SPZ), protects against malaria. We conducted this clinical trial to assess the safety and efficacy of PfSPZ Vaccine in HIV positive [...] ts received 5 doses of PfSPZ Vaccine or normal saline over 28 days followed by controlled human malaria infection (CHMI) 3 weeks later. RESULTS: There were no solicited adverse events in the 9 HIV- and
Semi-field experiments reveal contrasted predation and movement patterns of aquatic macroinvertebrate predators of Anopheles gambiae larvae (Publications)
BACKGROUND: Members of the Anopheles gambiae complex are major malaria vectors in sub-Saharan Africa. Their larval stages inhabit a variety of aquatic habitats in which, under natural circumstances, they [...] taxa of aquatic macroinvertebrate predators. Understanding the potential impact of predators on malaria vector larval population dynamics is important for enabling integrated local mosquito control programmes
Understanding the gap between access and use: a qualitative study on barriers and facilitators to insecticide-treated net use in Ghana (Publications)
a lack of information on the connection between the use of ITNs and malaria prevention. Falling ill or losing a loved one to malaria was the most powerful motivator for consistent ITN use. Participants
qRT-PCR versus IFA-based quantification of male and female gametocytes in low-density <em>Plasmodium falciparum</em> infections and their relevance... (Publications)
Accurate quantification of female and male gametocytes and sex ratios in asymptomatic low-density malaria infections are important for assessing their transmission potential. Gametocytes often escape detection [...] negligible for human-to-mosquito transmission.Estimating the transmission potential of ultralow-density malaria infections informs interventions. Almost all infections with > /=1 female and male gametocyte per
Antiparasitic chaiyaphumines from entomopathogenic <em>Xenorhabdus</em> sp. PB61.4 (Publications)
(1) showed good activity against Plasmodium falciparum (IC50 of 0.61 muM), the causative agent of malaria, and was active against other protozoal tropical disease causing agents
Causes of fever in returning travelers: a European multicenter prospective cohort study (Publications)
diagnostic algorithm was used ensuring a systematic evaluation of all participants. After ruling out malaria, PCRs and serologies for dengue, chikungunya and Zika viruses were performed in all patients presenting
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimise these compounds
Discovery and optimisation studies of antimalarial phenotypic hits (Publications)
a mammalian cell line (L6). One example showed no significant activity against a rodent model of malaria, and more work is needed to optimise these compounds
Antiplasmodial activity of a series of 1,3,5-triazine-substituted polyamines (Publications)
some parasitic protozoa and it is proposed that the pathway might also represent a target in the malaria parasite Plasmodium falciparum. A series of 1,3,5-triazine-substituted polyamine analogues were tested
