Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents (Publications)
thiolactomycin (TLM) have been synthesised and evaluated for their ability to inhibit the growth of the malaria parasite, Plasmodium falciparum. Thiolactomycin is an inhibitor of Type II fatty acid synthase which
<em>Plasmodium</em> gene regulation: far more to factor in (Publications)
Gene expression in the malaria parasite has received generous attention over the past several decades, predominantly because of the importance of var gene regulation, which is key to antigenic variation
Novel nucleoside-based antimalarial compounds (Publications)
The malaria-causing parasite Plasmodium falciparum employs a salvage pathway for the biosynthesis of nucleotides, in contrast to de novo biosynthesis that is utilized by the human host. A series of twenty-two
Modified 5'-trityl nucleosides as inhibitors of <em>Plasmodium falciparum</em> dUTPase (Publications)
dine triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for the treatment of malaria. We previously reported the discovery of 5'-tritylated analogues of deoxyuridine as selective inhibitors
Impact Stories | Swiss TPH (Page)
https://www.swisstph.ch/en/impact-stories
research. Read more 22.04.2021 Julia Richter, Swiss Malaria Group World Malaria Day 2021: In the shadows of the COVID-19 pandemic A world without malaria is within reach. At the same time, the COVID-19 pandemic [...] progress in the fight against malaria. This year's World Malaria Day on 25 April 2021 will draw attention to the fact that further efforts are needed to achieve the goal of a malaria-free world. Read more 21 [...] years, much has been invested in malaria prevention and treatment,...
Arthropod Testing Facility | Swiss TPH (Page)
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Mosquitoes on Behalf of Target Malaria ViALLIN MUsAcc - Visual Analysis of Long Lasting Insecticidal Nets to Maximise Universal Access Related Topics Infectious Diseases Malaria Human African Trypanosomiasis
Assessing the population coverage of a health demographic surveillance system using satellite imagery and crowd-sourcing (Publications)
in Malawi. The Majete Malaria Project Health and Demographic Surveillance System, in Malawi, started in 2014 to support a project with the aim of studying the reduction of malaria using an integrated control
Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery (Publications)
accelerate drug discovery for diseases of poverty, the Medicines for Malaria Venture (MMV) has released box sets of 400 compounds named the Malaria, Pathogen and Stasis Boxes. Here, we screened the Pathogen Box
Mapping of research on maternal health interventions in low- and middle-income countries: a review of 2292 publications between 2000 and 2012 (Publications)
systems strengthening, health promotion; and on five tracer conditions (haemorrhage, hypertension, malaria, HIV and other sexually transmitted infections (STIs)). Following review of 35,078 titles and abstracts [...] More than half the studies were done in sub-Saharan Africa (55.4 %), mostly addressing HIV and malaria. This region had low numbers of publications per hypertension and haemorrhage deaths, though South
Operational challenges to continuous LLIN distribution: a qualitative rapid assessment in four countries (Publications)
BACKGROUND: The World Health Organization recommends that long-lasting insecticidal nets (LLINs) for malaria prevention should be distributed continuously through antenatal care (ANC) and the expanded programme [...] participants were included (23 in Kenya, 13 in Malawi, 18 in Mali and 16 in Rwanda), drawn from malaria programmes, ANC and EPI programmes, government logistics units, and partner organizations. Interviews