Multi-center screening of the Pathogen Box collection for schistosomiasis drug discovery (Publications)
accelerate drug discovery for diseases of poverty, the Medicines for Malaria Venture (MMV) has released box sets of 400 compounds named the Malaria, Pathogen and Stasis Boxes. Here, we screened the Pathogen Box
Modifications and hybrids of 1,2,3,4‑tetrahydropyridinium salts and their antiprotozoal potencies (Publications)
were investigated for their activity against Plasmodium falciparum NF54, a causative organism of Malaria tropica and Trypanosoma brucei rhodesiense, the causative organism of Human African Trypanosomiasis
<em>Plasmodium</em> sensitivity to artemisinins: magic bullets hit elusive targets (Publications)
the genetic basis of laboratory-induced or field-observed altered susceptibility is crucial for malaria control. In this review different models of artemisinins' molecular action are briefly presented
Modifications and hybrids of 1,2,3,4‑tetrahydropyridinium salts and their antiprotozoal potencies (Publications)
were investigated for their activity against Plasmodium falciparum NF54, a causative organism of Malaria tropica and Trypanosoma brucei rhodesiense, the causative organism of Human African Trypanosomiasis
<em>Plasmodium</em> sensitivity to artemisinins: magic bullets hit elusive targets (Publications)
the genetic basis of laboratory-induced or field-observed altered susceptibility is crucial for malaria control. In this review different models of artemisinins' molecular action are briefly presented
Diseases and Programmes | Swiss TPH (Page)
https://www.swisstph.ch/en/about/scih/diseases-and-programmes
(ESHIA) in Burkina Faso on the use of genetically modified mosquitoes (GMMs) for future malaria control. Target Malaria - a vector control research collaborative based at Imperial College, London - aims to [...] evaluations; and (iii) poverty-related diseases such as Neglected Tropical Diseases, tuberculosis and malaria. From validation to application and health impact assessment We pay particular attention to “access” [...] to develop genetic technologies to modify mosquitoes to ultimately...
Vector Research and Control (Page)
https://www.swisstph.ch/en/about/eph/vector-biology/vector-research-and-control
Arch Tierheilkd . 2023;165(5):321-331. DOI: 10.17236/sat00395 Related Topics Malaria More to Explore Dynamical Modelling Malaria Initiative Related Activities Preclinical Research Arthropod Testing Facility [...] particularly important vectors as they spread some of the most devastating infectious diseases such as malaria, dengue fever, West Nile fever or Zika virus infections. Investigation of Vectors and Development [...] Study of a Self-Limiting Nondrive Strain of Genetically Modified...
Estimation of the antirelapse efficacy of tafenoquine, using <em>Plasmodium vivax</em> genotyping (Publications)
Plasmodium vivax relapse prevention is a key treatment goal in malaria. Use of P. vivax genotyping in a multicenter, double-blind, randomized, placebo-controlled Phase IIb study in Peru, India, Thailand
Imidazolopiperazines: lead optimization of the second-generation antimalarial agents (Publications)
mice. The optimized compounds were found to be more efficacious than the current antimalarials in a malaria mouse model. They exhibit moderate oral exposure in rat pharmacokinetic studies to achieve sufficient
Using observed incidence to calibrate the transmission level of a mathematical model for <em>Plasmodium vivax</em> dynamics including case management... (Publications)
model is used to calculate local reproduction numbers in Panama and identify areas of sustained malaria transmission that should be targeted by control interventions.