Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the <em>Plasmodium falciparum</em> dUTPase (Publications)
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) is a potential drug target for malaria. We previously reported some 5'-tritylated deoxyuridine analogues (both cyclic and acyclic) as selective
Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities (Publications)
plausible explanation for lack of significant activity of the inhibitors in the in vivo Pb mouse malaria model
Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary... (Publications)
Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development
Evaluation of ethnobotanically selected Benin medicinal plants for their in vitro antiplasmodial activity (Publications)
Twenty extracts from nine Benin medicinal plants, traditionally used to treat malaria, were screened for in vitro antiplasmodial activity towards Plasmodium falciparum K1 chloroquine resistant and 3D7
Abnormal blood glucose concentrations on admission to a rural Kenyan district hospital: prevalence and outcome (Publications)
a on admission was 7.3%. Severe illness, malnutrition, last meal > 12 hours ago, and a positive malaria slide were independently associated with hypoglycaemia. Overall, mortality in hypoglycaemic children
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models (Publications)
(OZ277) is a promising antimalarial drug candidate that Ranbaxy Laboratories Limited and Medicines for Malaria Venture (MMV) are currently developing as a fixed combination with piperaquine. Here, we describe
Discovery of a quinoline-4-carboxamide derivative with a novel mechanism of action, multistage antimalarial activity, and potent in vivo efficacy (Publications)
pharmacokinetic profile led to several compounds showing excellent oral efficacy in the P. berghei malaria mouse model with ED90 values below 1 mg/kg when dosed orally for 4 days. The favorable potency,
South-East Asia (Publications)
reduced the prevalence of parasitic diseases, but the emergence and spread of artemisinin-resistant malaria and multidrug-resistant (MDR) TB, along with the widespread use of often poor-quality anti-infective
<em>In silico</em> guided reconstruction and analysis of ICAM-1-binding var genes from <em>Plasmodium falciparum</em> (Publications)
the surface of infected erythrocytes is thought to play a major role in the pathology of severe malaria. As the sequence pool of the var genes encoding PfEMP1 expands there are opportunities, despite the
Validation of the protein kinase <em>Pf</em>CLK3 as a multistage cross-species malarial drug target (Publications)
target for drugs, with the potential to offer a cure-to be prophylactic and transmission blocking in malaria.