Searched for malaria.

1. Significant geographical differences in prevalence of mutations associated with <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> drug... (Publications)

   Significant geographical differences in prevalence of mutations associated with <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> drug resistance in two regions from Papua New Guinea

   Relevance:

   resistance remains a major obstacle to malaria treatment and control. It can arise and spread rapidly, and vary substantially even at sub-national level. National malaria programmes require cost-effective and

2. Gene Coverage Count and Classification (GC3): a locus sequence coverage assessment tool using short-read whole genome sequencing data, and its... (Publications)

   Gene Coverage Count and Classification (GC3): a locus sequence coverage assessment tool using short-read whole genome sequencing data, and its application to identify and classify histidine-rich protein 2 and 3 deletions in <em>Plasmodium falciparum</em>

   Relevance:

   BACKGROUND: The ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3

3. The <em>Plasmodium falciparum</em> histone methyltransferase PfSET10 is dispensable for the regulation of antigenic variation and gene expression in... (Publications)

   The <em>Plasmodium falciparum</em> histone methyltransferase PfSET10 is dispensable for the regulation of antigenic variation and gene expression in blood-stage parasites

   Relevance:

   The malaria parasite Plasmodium falciparum employs antigenic variation of the virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1) to escape adaptive immune responses during blood infection [...] for life cycle progression in the mosquito vector or during liver stage development.IMPORTANCEThe malaria parasite Plasmodium falciparum infects hundreds of millions of people every year. To survive and

4. Relationship between insecticide resistance profiles in <em>Anopheles gambiae</em> <em>sensu lato</em> and agricultural practices in Côte... (Publications)

   Relationship between insecticide resistance profiles in <em>Anopheles gambiae</em> <em>sensu lato</em> and agricultural practices in Côte d'Ivoire

   Relevance:

   BACKGROUND: Insecticide-based malaria vector control is increasingly undermined due to the development of insecticide resistance in mosquitoes. Insecticide resistance may partially be related to the use [...] s between the type of agricultural practices and certain insecticide resistance profiles in the malaria vector An. gambiae s.l. which might arise from the use of pesticides deployed for protecting crops

5. Pharmacokinetics of ivermectin metabolites and their activity against <em>Anopheles stephensi </em>mosquitoes (Publications)

   Pharmacokinetics of ivermectin metabolites and their activity against <em>Anopheles stephensi </em>mosquitoes

   Relevance:

   treat worm infections and ectoparasites including lice and scabies mites. Furthermore, survival of malaria transmitting Anopheles mosquitoes is strongly decreased after feeding on humans recently treated [...] . Currently, mass drug administration of ivermectin is under investigation as a potential novel malaria vector control tool to reduce Plasmodium transmission by mosquitoes. A "post-ivermectin effect" has

6. “I Believe That Pharmaceutical Companies Can Do More than Providing Medicines” (Page)

   “I Believe That Pharmaceutical Companies Can Do More than Providing Medicines”

   Relevance:
   https://www.swisstph.ch/en/impact-stories/i-believe-that-pharmaceutical-companies-can-do-more-than-providing-medicines

   and bring medicines to market in low- and middle-income countries. We work on diseases such as malaria, leishmaniasis and dengue fever, which primarily affect poorer countries and marginalised communities [...] development of new medicines. We can’t tackle tomorrow’s challenges with the tools of yesterday. In malaria, where there hasn’t been a new medicine in 25 years, drug resistance is on the rise. Novartis, together [...] these communities. The success we have achieved as a global community...

7. Host cytoskeleton remodeling throughout the blood stages of <em>Plasmodium falciparum</em> (Publications)

   Host cytoskeleton remodeling throughout the blood stages of <em>Plasmodium falciparum</em>

   Relevance:

   asexual intraerythrocytic development of Plasmodium falciparum, causing the most severe form of human malaria, is marked by extensive host cell remodeling. Throughout the processes of invasion, intracellular

8. Predictors of residual antimalarial drugs in the blood in community surveys in Tanzania (Publications)

   Predictors of residual antimalarial drugs in the blood in community surveys in Tanzania

   Relevance:

   cross-sectional survey was conducted in 2015 in three regions of Tanzania with different levels of malaria endemicity. Interviews were conducted and blood samples collected through household surveys for further

9. Antiprotozoal activities of some constituents of <em>Markhamia tomentosa</em> (Bignoniaceae) (Publications)

   Antiprotozoal activities of some constituents of <em>Markhamia tomentosa</em> (Bignoniaceae)

   Relevance:

   bloodstream trypomastigotes of Trypanosoma brucei rhodesiense (the species responsible for human malaria, visceral leishmaniasis and African trypanosomiasis, respectively). Although compounds 1 and 2 exhibited

10. Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues (Publications)

    Solid phase synthesis and antiprotozoal evaluation of di- and trisubstituted 5'-carboxamidoadenosine analogues

    Relevance:

    rapid increase of resistance to drugs commonly used in the treatment of tropical diseases such as malaria and African sleeping sickness calls for the prompt development of new safe and efficacious drugs