<em>Plasmodium falciparum</em> merozoite surface protein 1 as asexual blood stage malaria vaccine candidate (Publications)
INTRODUCTION: Malaria represents a tremendous public health challenge in tropical and sub-tropical regions, and currently deployed control strategies are likely insufficient to drive elimination of malaria. Development [...] Development and improvement of malaria vaccines might be key to reduce disease burden. Vaccines targeting asexual blood stages of the parasite have shown limited efficacy when studied in human trials conducted [...] as one of the most promising approaches to provide immune...
Development of WHO recommendations for the final phase of elimination and prevention of re-establishment of malaria (Publications)
that all affected countries work toward the elimination of malaria, even those still experiencing a high burden of disease. However, malaria programs in the final phase of elimination or those working [...] and quality-controlled malaria guidelines. The WHO convened an external guideline development group to formulate recommendations for interventions to reduce or prevent malaria transmission in areas with [...] with very low- to low-transmission levels and those that have eliminated malaria....
Similar prevalence of <em>Plasmodium falciparum</em> and Non-<em>P. falciparum</em> malaria infections among schoolchildren, Tanzania (Publications)
ovale infections were single-species infections, and 35% of those were detected in low malaria endemic regions. P. malariae infections were predominantly (73%) co-infections with P. falciparum. P. vivax was [...] Achieving malaria elimination requires considering both Plasmodium falciparum and non-P. falciparum infections. We determined prevalence and geographic distribution of 4 Plasmodium spp. by performing PCR [...] during 2017. Among 3,456 schoolchildren, 22% had P. falciparum, 24% had P....
A chromosomal reference genome sequence for the malaria mosquito <em>Anopheles gambia, </em>Giles, 1902, Ifakara strain (Publications)
We present a genome assembly from an individual female Anopheles gambiae (the malaria mosquito; Arthropoda; Insecta; Diptera; Culicidae), Ifakara strain. The genome sequence is 264 megabases in span. Most
A randomized, double-blind placebo-control study assessing the protective efficacy of an odour-based 'push-pull' malaria vector control strategy in... (Publications)
Novel malaria vector control strategies targeting the odour-orientation of mosquitoes during host-seeking, such as 'attract-and-kill' or 'push-and-pull', have been suggested as complementary tools to indoor [...] densities using light-traps. None of the interventions provided any protection from outdoor biting malaria vectors. The 'push' reduced indoor vector densities dominated by Anopheles funestus by around two
The MTego trap: a potential tool for monitoring malaria and arbovirus vectors (Publications)
used interchangeably with the BGP trap for sampling anthropophilic mosquitoes including African malaria vectors An. gambiae and An. funestus and the principal arbovirus vector Ae. aegypti.
Starting at the community: treatment-seeking pathways of children with suspected severe malaria in Uganda (Publications)
than five years with suspected severe malaria. An observational study in Uganda enrolled children below five years presenting to CHWs with signs of severe malaria. Children were followed up 28 days after [...] Community health workers (CHW) usually refer children with suspected severe malaria to the nearest public health facility or a designated public referral health facility (RHF). Caregivers do not always
Spatio-temporal modelling of routine health facility data for malaria risk micro-stratification in mainland Tanzania (Publications)
probability of malaria TPR exceeding programmatic threshold was estimated. Results showed a marked spatial heterogeneity in malaria TPR across wards. 17.7 million people resided in areas where malaria TPR was [...] As malaria transmission declines, the need to monitor the heterogeneity of malaria risk at finer scales becomes critical to guide community-based targeted interventions. Although routine health facility [...] million people lived in areas where malaria TPR was very low ( < 5%; 90%...