Efficacy and safety of the RTS,S/AS01 malaria vaccine during 18 months after vaccination: a phase 3 randomized, controlled trial in children and young... (Publications)
BACKGROUND: A malaria vaccine could be an important addition to current control strategies. We report the safety and vaccine efficacy (VE) of the RTS,S/AS01 vaccine during 18 mo following vaccination at [...] at 11 African sites with varying malaria transmission. METHODS AND FINDINGS: 6,537 infants aged 6-12 wk and 8,923 children aged 5-17 mo were randomized to receive three doses of RTS,S/AS01 or comparator [...] comparator vaccine. VE against clinical malaria in children during the 18 mo after...
The exit interview as a proxy measure of malaria case management practice: sensitivity and specificity relative to direct observation (Publications)
sensitivity and specificity of exit interviews as a measure of malaria case management practice as compared to direct observation.MethodsThe malaria case management of 1654 febrile patients attending 110 health [...] specificity from 70.6% to 98.1%.ConclusionThe exit interview appears to be a valid measure of objective malaria case management practices such as the completion of a diagnostic test or the provision of antimalarial [...] but may be a less valid measure of low frequency, subjective...
Managing the sick child in the era of declining malaria transmission: development of ALMANACH, an electronic algorithm for appropriate use of... (Publications)
based on a respiratory rate threshold of 50 assessed twice for febrile children 12-59 months; iv) malaria rapid diagnostic test performed for all febrile children. In the absence of identified source of
Age-shifting in malaria incidence as a result of induced immunological deficit: a simulation study (Publications)
Effective population-level interventions against Plasmodium falciparum malaria lead to age-shifts, delayed morbidity or rebounds in morbidity and mortality whenever they are deployed in ways that do not [...] shifting of incidence induced by either pre-erythrocytic vaccination (PEV) programmes or seasonal malaria chemo-prevention (SMC), using an ensemble of individual-based stochastic simulation models of P. [...] life-cycle and on human demography. Effects of transmission intensity, and of...
Applications and limitations of Centers for Disease Control and Prevention miniature light traps for measuring biting densities of African malaria... (Publications)
BACKGROUND: Measurement of densities of host-seeking malaria vectors is important for estimating levels of disease transmission, for appropriately allocating interventions, and for quantifying their impact [...] methods for their consistency in sampling indoor-feeding mosquitoes belonging to the two major taxa of malaria vectors across Africa, the Anopheles gambiae sensu lato complex and the Anopheles funestus s.l. group [...] easy to deploy on a large scale. Spatial and temporal variation in...
Feasibility and acceptability of injectable artesunate for the treatment of severe malaria in the Democratic Republic of Congo (Publications)
The Democratic Republic of the Congo (DRC) changed its national policy for the treatment of severe malaria in both children and adults in 2012 from intravenous quinine to injectable artesunate. The country [...] deploy nationwide injectable artesunate as the preferred treatment for the management of severe malaria. To support this process, the feasibility and acceptability of the use of injectable artesunate in [...] CONCLUSIONS: These findings show that the use of injectable artesunate for the...
Spatial and temporal variation of malaria entomological parameters at the onset of a hydro-agricultural development in central Côte d'Ivoire (Publications)
e heterogeneity of malaria transmission is essential for the design of effective prevention, control and elimination interventions. The spatial and temporal distribution of malaria vectors was investigated [...] correlated with malaria transmission. CONCLUSION: In this study setting, located in the bioclimatic transition zone of Cote d'Ivoire, rice cultivation was not observed to increase malaria transmission. The [...] observed in two of the five villages located in close proximity to the dam...
Artemether-lumefantrine treatment of uncomplicated <em>Plasmodium falciparum</em> malaria: a systematic review and meta-analysis of day 7 lumefantrine... (Publications)
BACKGROUND: Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well [...] data from patients treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria, to define therapeutic day 7 lumefantrine concentrations and identify patient factors that substantially [...] associated with > 98 % cure rates (if parasitemia /=200 ng/ml and high cure...
Distribution of malaria exposure in endemic countries in Africa considering country levels of effective treatment (Publications)
BACKGROUND: Malaria prevalence, clinical incidence, treatment, and transmission rates are dynamically interrelated. Prevalence is often considered a measure of malaria transmission, but treatment of clinical [...] clinical malaria reduces prevalence, and consequently also infectiousness to the mosquito vector and onward transmission. The impact of the frequency of treatment on prevalence in a population is generally [...] generally not considered. This can lead to potential underestimation of ma...
Assessment of parental perception of malaria vaccine in Tanzania (Publications)
and willingness to use malaria vaccines and to provide policy makers with evidence-based information on the best strategies to engage communities to manage the introduction of malaria vaccine in Tanzania [...] variables of interests were awareness and willingness to use a malaria vaccine. The main outcome measure was willingness to use a malaria vaccine. Logistic regression was used to examine the influence [...] BACKGROUND: Clinical trials of the RTS,S malaria vaccine have completed Phase III...