Low quality of routine microscopy for malaria at different levels of the health system in Dar es Salaam (Publications)
confirm malaria cases in Tanzania is low and presumptive treatment of malaria is being practiced widely. In malaria endemic areas WHO now recommends systematic laboratory testing when suspecting malaria. Currently [...] Currently, the use of Rapid Diagnostic Tests (RDTs) is recommended for the diagnosis of malaria in lower level peripheral facilities, but not in health centres and hospitals. In this study, the following [...] quality of routine microscopy, and (2) the effects of RDT...
Malaria treatment in the retail sector: knowledge and practices of drug sellers in rural Tanzania (Publications)
of Kilombero and Ulanga, Tanzania, we interviewed 489 shopkeepers about their knowledge of malaria and malaria treatment. A complementary mystery shoppers study was conducted in 118 retail outlets in order [...] general shops. RESULTS: Shopkeepers in drug stores were able to name more malaria symptoms and were more knowledgeable about malaria treatment than their peers in general shops. In drug stores, 52% mentioned [...] case. CONCLUSIONS: The quality of malaria case-management in the retail...
Estimating the burden of malaria in Senegal: Bayesian zero-inflated binomial geostatistical modeling of the MIS 2008 data (Publications)
(CRDH) with the technical assistance of ICF Macro and the National Malaria Control Programme (NMCP) conducted in 2008/2009 the Senegal Malaria Indicator Survey (SMIS), the first nationally representative household [...] household survey collecting parasitological data and malaria-related indicators. In this paper, we present spatially explicit parasitaemia risk estimates and number of infected children below 5 years. [...] infected children under the age of 5 years is Kolda (13940). The...
Mapping malaria risk among children in Côte d'Ivoire using Bayesian geo-statistical models (Publications)
estimated 767,000 disability-adjusted life years are due to malaria, placing the country at position number 14 with regard to the global burden of malaria. Risk maps are important to guide control interventions [...] ons, and hence, the aim of this study was to predict the geographical distribution of malaria infection risk in children aged
Rifampicin/Cotrimoxazole/Isoniazid versus mefloquine or quinine + sulfadoxine- pyrimethamine for malaria: a randomized trial1 (Publications)
multicentric noninferiority trial to assess the safety and efficacy of Cotrifazid against drug-resistant malaria in Papua New Guinea. DESIGN: The trial design was open-label, block-randomised, comparative, and [...] Sepik Province, Papua New Guinea. PARTICIPANTS: Patients of all ages with recurrent uncomplicated malaria were included. INTERVENTIONS: Patients were randomly assigned to receive Cotrifazid, mefloquine, [...] makes Cotrifazid in its current formulation and regimen a poor alternative...
First clinical trial of purified, irradiated malaria sporozoites in humans (Publications)
Evaluation of: Epstein JE, Tewari K, Lyke KE et al. Live attenuated malaria vaccine designed to protect through hepatic CD8 T cell immunity. Science 334(6055), 475-480 (2011). Purified, irradiated, me [...] route in humans are warranted to fully explore the potential of purified, attenuated sporozoites for malaria vaccine development
Functional and structural similarity of Vgamma9Vdelta2 T cells in humans and Aotus monkeys, a primate infection model for <em>Plasmodium falciparum... (Publications)
gammadelta T cells are implicated to play crucial roles during early immune responses to pathogens. A subset of human gammadelta T cells carrying the Vgamma9Vdelta2 TCR recognize small, phosphorylated