Malaria vaccines: a toy for travelers or a tool for eradication? (Publications)
efficacy of two candidate malaria vaccines in children living in malaria-endemic areas, namely RTS,S from the circumsporozoite protein that reduced infection and clinical malaria in Mozambique, and an asexual [...] visiting malaria-endemic areas, the usefulness of the first generation of malaria vaccine(s) will be limited, since the level of protection that is foreseen is unlikely to achieve that of malaria chemop [...] reduced parasite density in Papua New Guinea, allows one to believe that a m...
Effect of irrigation and large dams on the burden of malaria on a global and regional scale (Publications)
12.1% of the global malaria burden is concentrated. Whether an individual water project triggers an increase in malaria transmission depends on the contextual determinants of malaria, including the epi [...] conclude that in unstable malaria endemic areas, integrated malaria control measures, coupled with sound water management, are mandatory to mitigate the current burden of malaria in locations near irrigation [...] dynamics of malaria, but analyses of these environmental risk factors are...
Malaria elimination: moving forward with spatial decision support systems (Publications)
Operational challenges facing contemporary malaria elimination have distinct geospatial elements including the need for high-resolution location-based surveillance, targeted prevention and response in [...] mapping and geographical reconnaissance (GR) has traditionally played an important role in supporting malaria control and eradication, its full potential as an applied health systems tool has not yet been fully [...] spatial decision support system (SDSS) framework for supporting the...
Safety, tolerability and immunogenicity of new formulations of the <em>Plasmodium falciparum </em>malaria peptide SPf66 combined with the... (Publications)
SPf66 is a synthetic malaria peptide vaccine, which has been widely tested in combination with aluminium hydroxide (alum) as the adjuvant. Since this formulation is weakly immunogenic, we sought to improve
Rise in malaria incidence rates in South Africa: a small-area spatial analysis of variation in time trends (Publications)
analysis were that: 1) the spatial distribution of the rise in malaria incidence is uneven and strongly suggests a geographic expansion of high-malaria-risk areas; 2) there is evidence of a stabilization of incidence [...] Bayesian statistical models, the authors investigated spatial and temporal variations in small-area malaria incidence rates for the period mid-1986 to mid-1999 for two districts in northern KwaZulu Natal,