Willingness to use a rapid diagnostic test for malaria in a rural area of central Côte d'Ivoire (Publications)
elimination of malaria, particularly in areas where health services are deficient. The aim of this study was to determine knowledge, attitudes, practices and beliefs in relation to RDTs for malaria in rural [...] in Bozi and were offered an RDT for malaria were interviewed in April 2010 using a pre-tested questionnaire on practice and perceptions in relation to RDTs for malaria. The relationships between acceptance [...] an RDT. The concurrent availability and use of RDTs for HIV and malaria was...
Selection of mosquito life-histories: a hidden weapon against malaria? (Publications)
BACKGROUND: There has recently been a substantial decline in malaria incidence in much of Africa. While the decline can clearly be linked to increasing coverage of mosquito vector control interventions [...] be driving selection for a shift in mosquito life history that reduces their ability to transmit malaria parasites. Specifically it is hypothesized that by substantially increasing the extrinsic rate of [...] their resources towards greater short-term reproduction at the expense of...
Care-seeking patterns for fatal malaria in Tanzania (Publications)
health systems. Although patterns of care-seeking during uncomplicated malaria episodes are well known, studies in cases of fatal malaria are rare. Care-seeking behaviours may differ between these groups. [...] children less than five years of age with fatal malaria seen between 1999 and 2001 during over 240,000 person-years of follow-up in a stable perennial malaria transmission setting in southern Tanzania. Accounts [...] respectively. CONCLUSIONS: In this study of fatal malaria in southern...
The cost-effectiveness of intermittent preventive treatment for malaria in infants in Sub-Saharan Africa (Publications)
a pooled PE for IPTi with SP, malaria incidence, an estimated malaria case fatality rate of 1.57%, IPTi delivery costs and country specific provider and household malaria treatment costs. FINDINGS: In [...] effect on clinical malaria. CONCLUSIONS: IPTi delivered alongside the EPI is a highly cost effective intervention against clinical malaria with a range of drugs in a range of malaria transmission settings [...] treatment in infants (IPTi) has been shown to decrease clinical malaria by...
Malaria and urbanization in sub-Saharan Africa (Publications)
live in urban areas. Recognizing that malaria control can improve the health of the vulnerable and remove a major obstacle to their economic development, the Malaria Knowledge Programme of the Liverpool [...] School of Tropical Medicine and the Systemwide Initiative on Malaria and Agriculture convened a multi-sectoral technical consultation on urban malaria in Pretoria, South Africa from 2nd to 4th December, 2004 [...] 2004. The aim of the meeting was to identify strategies for the assessment...
A novel approach for measuring the burden of uncomplicated <em>Plasmodium falciparum</em> malaria: application to data from Zambia (Publications)
While the primary reason for treating malaria is to reduce disease burden, the effects of treatment are generally ignored in estimates of the burden of malaria morbidity, which are usually presented in [...] for estimating burden of disease based on the point prevalence of malaria attributable disease, or equivalently, the days with malaria fever in unit time. The technique makes use of data available from [...] patterns in malaria therapy patients, and data on recall bias. Application of this...
MalHaploFreq: a computer programme for estimating malaria haplotype frequencies from blood samples (Publications)
are important surveillance tools that can inform policy choice. People infected with falciparum malaria often contain several genetically-distinct clones of the parasite; genotyping the patients' blood [...] present (i.e. its prevalence), but does not reveal its frequency. For example a person with four malaria clones may contain both mutant and wildtype forms of a marker but it is not possible to distinguish
Residual antimalarials in malaria patients from Tanzania - implications on drug efficacy assessment and spread of parasite resistance (Publications)
BACKGROUND: Repeated antimalarial treatment for febrile episodes and self-treatment are common in malaria-endemic areas. The intake of antimalarials prior to participating in an in vivo study may alter treatment [...] n of both efficacy and safety outcomes. We report the findings from baseline plasma sampling of malaria patients prior to inclusion into an in vivo study in Tanzania and discuss the implications of residual
