A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria (Publications)
Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in combating [...] combating malaria requires development of new, easy to administer drug combinations with broad-ranging activity against all manifestations of the disease. DSM265, a triazolopyrimidine-based inhibitor of [...] dehydrogenase (DHODH), is the first DHODH inhibitor to reach clinical...
Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3,... (Publications)
were the occurrence of malaria over 12 months after dose 3 in each age category. In this final analysis, we present data for the efficacy of the booster on the occurrence of malaria. Vaccine efficacy (VE) [...] (VE) against clinical malaria was analysed by negative binomial regression and against severe malaria by relative risk reduction. This trial is registered with ClinicalTrials.gov, number NCT00866619. FINDINGS: [...] children who experienced at least one episode of severe malaria in the...
Histone methyltransferase inhibitors are orally bioavailable, fast acting molecules with activity against different species causing malaria in humans (Publications)
antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite killing activity with the histone
Acquisition of antibodies against <em>Plasmodium falciparum</em> merozoites and malaria immunity in young children: influence of age, force of... (Publications)
levels were not associated with protection from malaria; in contrast, they were typically associated with an increased risk of malaria. Adjustment for malaria exposure, using a novel molecular measure of [...] subclasses) to merozoite antigens and their relationship to the prospective risk of malaria in children aged 1-4yrs in a malaria endemic region of Papua New Guinea. IgG, IgG1 and IgG3 responses generally increased [...] required for protection from malaria. Our results suggest that in...
Mass screening and treatment on the basis of results of a <em>Plasmodium</em> <em>falciparum</em>-specific rapid diagnostic test did not reduce... (Publications)
reaction (PCR) analyses. Data on confirmed malaria infections from health facilities in intervention and hotspot control areas were monitored as proxy for malaria transmission. RESULTS: Approximately 64% [...] carriers) did not reduce subsequent malaria incidence compared with control areas. CONCLUSIONS: Highly sensitive point-of-care diagnostic tools for detection of all human malaria species are needed to make MSAT [...] BACKGROUND: Seasonal increases in malaria continue in hotspots in...
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children (Publications)
vaccination with either RTS,S/AS01 or a non-malaria comparator vaccine. The primary end point of the analysis was vaccine efficacy against clinical malaria during the 12 months after vaccination in the [...] vaccine according to protocol. After 250 children had an episode of severe malaria, we evaluated vaccine efficacy against severe malaria in both age categories. Results In the 14 months after the first dose [...] against severe malaria was 45.1% (95% CI, 23.8 to 60.5) in the...
Design of a phase III cluster randomized trial to assess the efficacy and safety of a malaria transmission blocking vaccine (Publications)
falciparum malaria transmission targeting sexual, sporogonic, or mosquito-stage antigens (SSM-VIMT) are currently under development to reduce malaria transmission. An international group of malaria experts [...] estimates suggest that such a trial is feasible, and within the range of previously supported trials of malaria interventions, although substantial issues to implementation exist.
