Malaria seasonality and rainfall seasonality in Sri Lanka are correlated in space (Publications)
seasonality of malaria and seasonality of rainfall was studied in Sri Lanka. A simple seasonality index was developed by making use of the bimodal seasonality of both malaria and rainfall. The malaria seasonality [...] rainfall seasonality index in explaining the malaria seasonality index was found to be significant. The results suggest that rainfall is an important driver of malaria seasonality
Mapping and predicting malaria transmission in the People's Republic of China, using integrated biology-driven and statistical models (Publications)
humidity, which thus determines the extent of malaria transmission. However, in regions with relative humidity > 60%, temperature is the major driver of malaria transmission intensity. By integrating bio [...] The purpose of this study was to deepen our understanding of Plasmodium vivax malaria transmission patterns in the People's Republic of China (P.R. China). An integrated modeling approach was employed [...] and statistical models. A Delphi approach was used to determine environmental...
Pyrethroid resistance in <em>Anopheles gambiae</em>, in Bomi County, Liberia, compromises malaria vector control (Publications)
the efficacy of malaria strategies relying on this class of insecticide. The findings highlight the urgent need to expand and sustain monitoring of insecticide resistance in Liberian malaria vectors, evaluate [...] Lasting Insecticidal Nets (LLIN) and Indoor Residual Spraying (IRS) have both proven to be effective malaria vector control strategies in Africa and the new technology of insecticide treated durable wall lining [...] is logistically challenging and, furthermore, the increase in...
Generalized seasonal autoregressive integrated moving average models for count data with application to malaria time series with low case numbers (Publications)
The models were applied to monthly malaria case time series in a district in Sri Lanka, where malaria has decreased dramatically in recent years. RESULTS: The malaria series showed long-term changes in [...] INTRODUCTION: With the renewed drive towards malaria elimination, there is a need for improved surveillance tools. While time series analysis is an important tool for surveillance, prediction and for measuring [...] on in the series. CONCLUSIONS: G(S)ARIMA models may be particularly useful...
Modeling the public health impact of malaria vaccines for developers and policymakers (Publications)
of malaria vaccines as complements to existing interventions. However, the complexity of such models may make their outputs inaccessible to non-modeling specialists. This paper describes a Malaria Vaccine [...] BACKGROUND: Efforts to develop malaria vaccines show promise. Mathematical model-based estimates of the potential demand, public health impact, and cost and financing requirements can be used to inform [...] functionality was demonstrated by estimating the public health impact of a...
Over-diagnosis of malaria by microscopy in the Kilombero Valley, Southern Tanzania: an evaluation of the utility and cost-effectiveness of rapid... (Publications)
is the most common form of malaria diagnosis, concerns over its accuracy have prompted the incorporation of malaria rapid diagnostic tests (RDTs) into many national malaria control programmes. METHODS: [...] and accurate diagnosis of febrile patients is essential to treat uncomplicated malaria cases properly, prevent severe malaria, and avert unnecessary anti-malarial treatments. Improper use of anti-malarials [...] estimating the extent of malaria over-diagnosis and over-treatment with...
Population pharmacokinetics of mefloquine, piperaquine and artemether-lumefantrine in Cambodian and Tanzanian malaria patients (Publications)
BACKGROUND: Inter-individual variability in plasma concentration-time profiles might contribute to differences in anti-malarial treatment response. This study investigated the pharmacokinetics of thre
Malaria case management in Papua New Guinea prior to the introduction of a revised treatment protocol (Publications)
document malaria case management practices in Papua New Guinea prior to the introduction of a revised national malaria treatment protocol. The revised protocol stipulates routine testing of malaria infection [...] observation instrument. RESULTS: Overall, 15% of observed fever patients (n=468) were tested for malaria infection by rapid diagnostic test and a further 3.6% were tested via microscopy. An anti-malarial [...] what they might look like were discussed in only 1.1% of cases. CONCLUSION:...