“It is a privilege to be able to bring science to the bedside” – Elisabeth Reus on the launch of a new malaria clinical trial in the DRC (Blog)
https://www.swisstph.ch/en/impact-stories/it-is-a-privilege-to-be-able-to-bring-science-to-the-bedside/blog-id/83
Elisabeth Reus, Head of the Clinical Operations unit at Swiss TPH, is currently in the Democratic Republic of the Congo (DRC) to launch the phase IIb trial of a new antimalarial drug in collaboration
Malaria | Swiss TPH (Page)
https://www.swisstph.ch/en/topics/malaria
Accelerating the Fight against Malaria - World Malaria Day 2024 New Malaria Medicines Accept Show More Key Facts About Malaria Malaria is a Major Disease Burden Malaria is a disease caused by parasites [...] Training for Malaria Control and Elimination since 2017. Our focus areas Antimalarial Drug Development Basic Malaria Research Diagnosis and Treatment Malaria Elimination Malaria Host Interactions Malaria Intervention [...] Medicines for Malaria Venture Malaria Consortium RBM Partnership to...
Basic Malaria Research (Page)
https://www.swisstph.ch/en/topics/malaria/basic-malaria-research
Basic Malaria Research We acquire new functional and mechanistic insight into processes linked to the essential biology of malaria blood stage parasites. These parasite forms are responsible for all m [...] signatures associated with native and adaptive anti-malarial immunity in vivo . Malaria Antimalarial Drug Development Malaria Vaccines Project Highlights Scanning electron micrographs of an erythrocyte and [...] Commitment and Early Differentiation of Malaria Transmission Stages The project...
Malaria Elimination (Page)
https://www.swisstph.ch/en/topics/malaria/malaria-elimination
Malaria Elimination The malaria map is shrinking. In high burden areas malaria parasite prevalence has been reduced dramatically. Around 100 countries are now free from malaria. According to WHO estimates [...] strategies. Malaria Antimalarial Drug Development Malaria Vaccines Mosquito Biology and Control Project Highlights Malaria Diagnosis in Papua New Guinea Controlling and Eliminating Malaria in Southeast [...] estimates, malaria incidence (the rate of new malaria cases) fell by 37% between...
Malaria Intervention Studies (Page)
https://www.swisstph.ch/en/topics/malaria/malaria-intervention-studies
levels. Malaria Elimination Surveillance and Health Systems Mosquito Biology and Control Project Highlights Community Access to Rectal Artesunate for Malaria (CARAMAL) Children with severe malaria need immediate [...] (RADZEC) In countries approaching malaria elimination, individual case-based surveillance and targeted response to individual malaria cases becomes a cornerstone of malaria control and elimination efforts [...] Reactive Case Detection implemented by the Zanzibar Malaria Elimination...
Malaria Vaccines (Page)
https://www.swisstph.ch/en/topics/malaria/malaria-vaccines
developing resistance to existing malaria drugs, and mosquitoes are developing resistance to insecticides. Malaria vaccines are potential new tools in combating malaria by targeting several different stages [...] decision making boards. Malaria Basic Malaria Research Antimalarial Drug Development Mosquito Biology and Control Project Highlights Health Impact and Cost-Effectiveness of Malaria Vaccines Swiss TPH has [...] Malaria Vaccines Recently, the malaria burden was successfully reduced as a...
CARAMAL | Swiss TPH Malaria Projects (Page)
https://www.swisstph.ch/en/about/med/medicines-implementation-research/caramal
CARAMAL - Community Access to Rectal Artesunate for Malaria Many malaria deaths occur in places where people have poor access to preventive and curative health services. Prompt access to quality care is [...] severe childhood diseases, among which severe malaria is particularly frequent in endemic areas of sub-Saharan Africa. Where parenteral treatment of severe malaria is not available, for example at the level [...] of care for severe malaria can be provided. Since 2018, two RAS products have...
The candidate blood-stage malaria vaccine P27A induces a robust humoral response in a fast track to the field phase I trial in exposed and non exposed... (Publications)
The present project aimed at evaluating the safety and immunogenicity of P27A peptide vaccine in malaria non-exposed European and exposed African adults. Methods: This study was designed as a staggered [...] GLA-SE (2.5 or 5mug), or control rabies vaccine (Verorab(R)) were administered intramuscularly to 16 malaria non-exposed and 40 exposed subjects on days 0, 28 and 56. Local and systemic adverse events (AEs) [...] an ADCI dependent mechanism. Incidence of AEs and antibody responses were...
Safety, immunogenicity, and protective efficacy against controlled human malaria infection of<em> Plasmodium falciparum</em> sporozoites vaccine in... (Publications)
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI) of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ) (PfSPZ Challenge) to try to reduce time [...] time and costs of developing PfSPZ Vaccine to prevent malaria in Africa. Immunization with five doses at 0, 4, 8, 12, and 20 weeks of 2.7 x 10(5) PfSPZ of PfSPZ Vaccine gave 65% vaccine efficacy (VE) at [...] and controls. Antibody responses to Pf circumsporozoite protein were...