Leveraging mathematical models of disease dynamics and machine learning to improve development of novel malaria interventions (Publications)
targeted reductions in malaria prevalence. METHODS: A mathematical model of malaria transmission dynamics is used to simulate deployment and predict potential impact of new malaria interventions by considering [...] mathematical models of malaria dynamics coupled with machine learning. Our analysis identifies requirements of efficacy, coverage, and duration of effect for five novel malaria interventions to achieve [...] achieve specified health goals. RESULTS: We apply our approach to five malar...
An affordable, quality-assured community-based system for high-resolution entomological surveillance of vector mosquitoes that reflects human malaria... (Publications)
Y: An intensive and extensive CB system for routine, longitudinal, programmatic surveillance of malaria vectors and other mosquitoes using the Ifakara Tent Trap (ITT-C) was developed in Urban Dar es Salaam [...] surveys using either ITT-C or human landing catches (HLC), as well as a cross-sectional survey of malaria parasite prevalence in the same housing compounds. RESULTS: Community-based ITT-C had much lower
Population pharmacokinetics and clinical response for artemether-lumefantrine in pregnant and nonpregnant women with uncomplicated <em>Plasmodium... (Publications)
Artemether-lumefantrine (AL) is the first-line treatment for uncomplicated malaria in the second and third trimesters of pregnancy. Its efficacy during pregnancy has recently been challenged due to altered [...] and assess their therapeutic outcome. Thirty-three pregnant women and 22 nonpregnant women with malaria were treated with AL (80/480 mg) twice daily for 3 days. All patients provided five venous plasma [...] this group, mostly due to lower posttreatment prophylaxis. Hence, a modified...
<em>In vitro</em> antiplasmodial screening of ethnopharmacologically selected South African plant species used for the treatment of malaria (Publications)
treatment of malaria and associated symptoms. To evaluate the in vitro antiplasmodial efficacy and cytotoxic properties of indigenous medicinal plants used by Venda people against malaria. MATERIALS AND