Gametocyte carriage in uncomplicated <em>Plasmodium falciparum</em> malaria following treatment with artemisinin combination therapy: a systematic... (Publications)
BACKGROUND: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite [...] pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important for malaria elimination efforts. An individual patient clinical data meta-analysis was undertaken to identify
Malaria parasites possess a telomere repeat-binding protein that shares ancestry with transcription factor IIIA (Publications)
characteristic MYB-type domain. Here, we identified the telomere repeat-binding protein PfTRZ in the malaria parasite Plasmodium falciparum, a member of the Alveolate phylum for which TRFs have not been described
Spatial distribution of<em> Falciparum</em> malaria infections in Zanzibar: implications for focal drug administration strategies targeting... (Publications)
Background.: Optimal use of mass/targeted screen-and-treat or mass or focal drug administration as malaria elimination strategies remains unclear. We therefore studied spatial distribution of Plasmodium
Mosquito behavior change after distribution of bednets results in decreased protection against malaria exposure (Publications)
efficacy of vector control in reducing malaria transmission. Methods.: In this study, we quantified human exposure to both bites and infective bites of a major malaria vector in Papua New Guinea over the [...] the course of 4 years surrounding nationwide bednet distribution. We also quantified malaria infection prevalence in the human population during the same time period. Results.: We observed a shift in mosquito [...] period and was lowest in the adult population, who may be an important...
Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar (Publications)
be targeted for malaria elimination. METHODS: A mass blood survey was conducted among 485 individuals from six villages in Kayah State, an area of endemic but low transmission malaria in eastern Myanmar [...] BACKGROUND: Myanmar has the heaviest burden of malaria in the Greater Mekong Sub-region. Asymptomatic Plasmodium spp. infections are common in this region and may represent an important reservoir of t [...] Myanmar. Malaria infection was screened by rapid diagnostic test (RDT), light...
Higher complexity of infection and genetic diversity of <em>Plasmodium vivax </em>than <em>Plasmodium falciparum</em> across all malaria transmission... (Publications)
New Guinea (PNG) to evaluate transmission dynamics across the country. In 2008-2009, a nationwide malaria indicator survey collected 8,936 samples from all 16 endemic provinces of PNG. Of these, 892 positive
Mefloquine at the crossroads? Implications for malaria chemoprophylaxis in Europa [Commentary] (Publications)
mefloquine. Some malaria prevention advisors question the scientific basis for the restrictions and suggest that this cost-effective, anti-malarial drug will be displaced as a first-line anti-malaria medication [...] the new recommendations for malaria prophylaxis that have been adapted by Switzerland, Germany, Austria and Italy where chemoprophylaxis use is restricted to high-risk malaria-endemic areas. [...] Since its introduction to the market in 1985, mefloquine has been used for malaria...
