Adherence to and acceptability of artemether-lumefantrine as first-line anti-malarial treatment: evidence from a rural community in Tanzania (Publications)
six-dose regimen of artemether-lumefantrine (AL) therapy for uncomplicated Plasmodium falciparum malaria results in cure rates > 95% with good tolerability. MATERIALS AND METHODS: A prospective study was [...] the context of the ALIVE study, a prospective, community-based, observational study in a rural, malaria-endemic area of Tanzania. Following microscopic confirmation of P. falciparum infection, the first
Estimating <em>Plasmodium falciparum</em> transmission rates in low-endemic settings using a combination of community prevalence and health facility... (Publications)
As some malaria control programs shift focus from disease control to transmission reduction, there is a need for transmission data to monitor progress. At lower levels of transmission, it becomes increasingly [...] studies. Many programs conduct regular cross sectional parasite prevalence surveys, and have access to malaria treatment data routinely collected by ministries of health, often in health management information
Imaging of <em>Plasmodium</em> liver stages to drive next-generation antimalarial drug discovery (Publications)
Most malaria drug development focuses on parasite stages detected in red blood cells, even though to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic forms [...] imidazolopiperazine confers complete causal prophylactic protection (15 mg/kg) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity. The open source chemical tools resulting
Micro-epidemiological structuring of <em>Plasmodium falciparum</em> parasite populations in regions with varying transmission intensities in Africa (Publications)
Background: The first models of malaria transmission assumed a completely mixed and homogeneous population of parasites. Recent models include spatial heterogeneity and variably mixed populations. However [...] pairs is predicted by relatedness in space and time. Conclusions: Our findings suggest that targeted malaria control will benefit the surrounding community, but unfortunately also that emerging drug resistance
Discovery and characterization of ACT-451840: an antimalarial drug with a novel mechanism of action (Publications)
More than 40 % of the world's population is at risk of being infected with malaria. Most malaria cases occur in the countries of sub-Saharan Africa, Central and South America, and Asia. Resistance to standard
Spatial and temporal characteristics of laboratory-induced <em>Anopheles coluzzii</em> swarms: shape, structure, and flight kinematics (Publications)
Malaria mosquitoes mate in swarms, but how these swarms are formed and maintained remains poorly understood. We characterized three-dimensional spatiotemporal flight kinematics of Anopheles coluzzii males [...] results in the observed elliptical cone swarm shape. We discuss the implications of these finding on malaria mosquito mating success, speciation and for vector control. © 2024 The Author(s)
Mosquito net use in early childhood and survival to adulthood in Tanzania (Publications)
BACKGROUND It has been hypothesized that in high-transmission settings, malaria control in early childhood (
Mosquito net use in early childhood and survival to adulthood in Tanzania (Publications)
BACKGROUND It has been hypothesized that in high-transmission settings, malaria control in early childhood (
Asymptomatic <em>Plasmodium</em> infection and glycemic control in adults: results from a population-based survey in south-central Côte d'Ivoire (Publications)
associations of Plasmodium infection (PI) with fasting glucose (FG) and glycated hemoglobin (HbA1c) in malaria-endemic south-central Cote d'Ivoire. METHODS: We studied 979 participants (non-pregnant; no treated [...] Fasting venous blood was obtained for PI, FG, and HbA1c assessment. We defined PI as a positive malaria rapid diagnostic test (RDT) or microscopic identification of Plasmodium species. We applied multivariable [...] diagnosis in the presence of asymptomatic PI may misclassify...
The influence of zinc supplementation on morbidity due to <em>Plasmodium falciparum</em>: a randomized trial in preschool children in Papua New Guinea (Publications)
determine the influence of zinc on malaria morbidity we conducted a randomized placebo-controlled trial of daily zinc supplementation in children residing in a malaria endemic region of Papua New Guinea [...] mg elemental zinc (n = 136) or placebo (n = 138) for 6 days a week for 46 weeks. Slide-confirmed malaria episodes were detected by surveillance of cases self-reporting to a local health center. Cross-sectional
