Polyamidoamine nanoparticles for the oral administration of antimalarial drugs (Publications)
mice, slightly improving the activity of the free drug and inducing in the animals immunity against malaria. Liquid chromatography with tandem mass spectrometry analysis of affinity chromatography-purified [...] coinfections such as Plasmodium and Leishmania. When fluorescein-labeled PAAs were fed to females of the malaria mosquito vectors Anopheles atroparvus and Anopheles gambiae, persistent fluorescence was observed
Do bednets including piperonyl butoxide offer additional protection against populations of<em> Anopheles gambiae s.l. </em>that are highly resistant... (Publications)
Malaria control is dependent on the use of longlasting insecticidal nets (LLINs) containing pyrethroids. A new generation of LLINs containing both pyrethroids and the synergist piperonyl butoxide (PBO) [...] (PBO) has been developed in response to increasing pyrethroid resistance in African malaria vectors, but questions remain about the performance of these nets in areas where levels of pyrethroid resistance
Activity refinement of aryl amino acetamides that target the <em>P. falciparum</em> STAR-related lipid transfer 1 protein (Publications)
Malaria is a devastating disease that causes significant morbidity worldwide. The development of new antimalarial chemotypes is urgently needed because of the emergence of resistance to frontline therapies [...] a useful tool for further investigating the druggability of PfSTART1 across the lifecycle of the malaria parasite.
From magic bullet to magic bomb: reductive bioactivation of antiparasitic agents (Publications)
human cells. Examples are the enzymes of folate synthesis or of the nonmevalonate pathway in the malaria parasites. However, there are other ways how a drug can kill selectively. Of particular relevance [...] the host, as this is how the current frontrunners of parasite chemotherapy work. Artemisinins for malaria, fexinidazole for human African trypanosomiasis, benznidazole for Chagas' disease, metronidazole
Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity (Publications)
The 2-phenoxybenzamide 1 from theMedicines for Malaria Venture Malaria Box Project has shown promising multi-stage activity against different strains of P. falciparum. It was successfully synthesized via
Medical Parasitology and Infection Biology | Departments of Swiss TPH (Page)
https://www.swisstph.ch/en/about/mpi
these biological processes, we hope to contribute to the control of diseases of poverty such as malaria, tuberculosis, trypanosomiasis, dengue, Buruli ulcer and helminth infections. Research on Pathogen [...] gagneux@swisstph.ch Clinical Immunology Gene Regulation Helminth Drug Development Helminth Immunology Malaria Host Interactions Parasite Chemotherapy Unit Tuberculosis Ecology and Evolution Unit Tuberculosis [...] Units and Groups Clinical Immunology Gene Regulation Helminth Drug...
First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: a meta-analysis of... (Publications)
artemisinin combination therapy regimens to treat malaria in early pregnancy are likely to outweigh the adverse outcomes of partially treated malaria, which can occur with oral quinine because of the known [...] safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances. We conducted a meta-analysis [...] antimalarial treatment. METHODS AND FINDINGS: Electronic databases including...
First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: a meta-analysis of... (Publications)
artemisinin combination therapy regimens to treat malaria in early pregnancy are likely to outweigh the adverse outcomes of partially treated malaria, which can occur with oral quinine because of the known [...] safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances. We conducted a meta-analysis [...] antimalarial treatment. METHODS AND FINDINGS: Electronic databases including...
The effect of <em>Plasmodium falciparum</em> exposure and maternal anti-circumsporozoite protein antibodies on responses to RTS,S/AS01E vaccination in... (Publications)
BACKGROUND: The RTS,S/AS01(E) malaria vaccine showed lower antibody response and protective efficacy in infants aged 6-12 weeks compared with children aged 5-17 months (for whom this vaccine is recommended) [...] antibody immunoglobulin G (IgG) responses measured by ELISA and pre-vaccination serological markers of malaria exposure by assessing the IgG levels against 1000 P falciparum antigens using partial proteome m [...] The negative effect of maternal anti-CSP IgG in infants did not appear to...
Targeting <em>Plasmodium </em>plasmepsin V: hitting two birds with one stone (Publications)
al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these