Inhibitors of Plasmepsin II-potential antimalarial agents (Publications)
In order to overcome the problem of drug resistance in malaria, it appears wise to concentrate drug discovery efforts toward new structural classes and new mechanisms of action. We report our results,
Long-lasting and fast-acting<em> in vivo</em> efficacious antiplasmodial azepanylcarbazole amino alcohol (Publications)
With approximately 429,000 deaths in 2016, malaria remains a major infectious disease where the need to treat the fever symptoms, but also to provide relevant post-treatment prophylaxis, is of major importance
DDT contamination in water resources of some African countries and its impact on water quality and human health (Publications)
use in indoor residual spraying (IRS) in developing countries, including African countries, for malaria control. There have been no previous reviews on DDT residues in water resources in Africa. The study [...] risk in sampled drinking sources within African water systems. Therefore, alternative methods for malaria vector control should be investigated and applied.
Activation of TCR Vδ1+ and Vδ1-Vδ2- γδ T cells upon controlled infection with <em>Plasmodium falciparum</em> in Tanzanian volunteers (Publications)
immune response to malaria remains incomplete. Clinical trials using whole-sporozoite-based vaccination approaches such as the Sanaria PfSPZ Vaccine, followed by controlled human malaria infection (CHMI)
<em>Plasmodium vivax</em> and <em>Plasmodium falciparum</em> infection dynamics: re-infections, recrudescences and relapses (Publications)
BACKGROUND: In malaria endemic populations, complex patterns of Plasmodium vivax and Plasmodium falciparum blood-stage infection dynamics may be observed. Genotyping samples from longitudinal cohort studies [...] CONCLUSION: The statistical model developed here provides a useful new tool for in-depth analysis of malaria data from longitudinal cohort studies, and future application to data sets with multi-locus genotyping
The Shockwè trap: a human-baited exposure-free device for surveillance and behaviour studies of anthropophilic vectors (Publications)
entomological inoculation rate (EIR) are common parameters routinely used to measure the risk of malaria transmission. Both parameters can be estimated using human landing catches (HLC). Although it is [...] human-exposure free device for monitoring the occurrence of a wide range of mosquito, including major malaria and arboviruses vector species. However, improvements are needed to increase its sampling efficiency
Elimination of <em>Schistosoma mansoni</em> in infected mice by slow release of artemisone (Publications)
anti-plasmodial activity, and reduced toxicity compared to other artemisinins in clinical use against malaria. We infected adult mice by subcutaneous injection of S. mansoni cercariae (about 200) and treated [...] release of the artemisone that was verified in vivo and in vitro bioassays using drug-sensitive malaria parasites. We found superior strong anti-schistosome effects up to a total reduction of worm number
A <em>Plasmodium falciparum</em> PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface (Publications)
Uniquely among malaria parasites, Plasmodium falciparum-infected erythrocytes (iRBCs) develop membrane protrusions, known as knobs, where the parasite adhesion receptor P. falciparum erythrocyte membrane [...] formation and the associated iRBC adherence to host endothelium are directly linked to the severity of malaria and are functional manifestations of protein export from the parasite to the iRBC. A family of exported
Multiplicity of <em>Plasmodium falciparum</em> infection following intermittent preventive treatment in infants (Publications)
Intermittent preventive treatment in infants with sulphadoxine-pyrimethamine (IPTi-SP) reduces malaria morbidity by 20% to 33%. Potentially, however, this intervention may compromise the acquisition of [...] of polyclonal infections (69.6% vs. 69.7%; P = 0.99). Adjusting for study site, current and prior malaria, parasite density, and season did not change this finding. CONCLUSIONS: IPTi-SP appears to have no
Transcription profiling of a recently colonised pyrethroid resistant <em>Anopheles gambiae</em> strain from Ghana (Publications)
resistance to the pyrethroid insecticides used to treat bednets threatens the sustainability of malaria control in sub-Saharan Africa. While the impact of target site insensitivity alleles is being widely [...] detoxification--though equally important--remains elusive. The successful development of new tools for malaria intervention and management requires a comprehensive understanding of insecticide resistance, including