malERA: an updated research agenda for health systems and policy research in malaria elimination and eradication (Publications)
effectiveness of interventions ('effectiveness decay'), and respond to dynamic and changing needs. The malaria eradication research agenda (malERA) Refresh consultative process for the Panel on Health Systems [...] Research identifies opportunities to build health systems evidence and the tools needed to eliminate malaria from different zones, countries, and regions and to eradicate it globally. The research questions [...] include delivery strategies to meet the changing dynamics of needs of...
Longitudinal estimation of <em>Plasmodium falciparum </em>prevalence in relation to malaria prevention measures in six sub-Saharan African countries (Publications)
(PfPR) is a widely used metric for assessing malaria transmission intensity. This study was carried out concurrently with the RTS,S/AS01 candidate malaria vaccine Phase III trial and estimated PfPR over [...] 3 sites. Surveys were usually performed during the peak malaria parasite transmission season, in one home visit, when medical history and malaria risk factors/prevention measures were collected, and a blood [...] 0.52, 0.68, 0.41) and bed net use in 2 surveys (ORs: 0.63, 0.68, 1.03, 1.78)...
Multiple insecticide resistance in <em>Anopheles gambiae</em> from Tanzania: a major concern for malaria vector control (Publications)
development of insecticide resistance in the major malaria vectors. This study was carried out to monitor the susceptibility status of major malaria vectors to insecticides used for IRS and LLINs in mainland [...] BACKGROUND: Malaria vector control in Tanzania is based on use of long-lasting insecticide treated nets (LLINs) and indoor residual spraying (IRS), which both rely on the use of chemical insecticides. [...] An. gambiae sensu stricto (s.s.) Kisumu strain. RESULTS: Anopheles arabiensis...
Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite <em>Plasmodium falciparum</em> (Publications)
bottleneck in the Plasmodium life cycle and a key intervention target of ongoing efforts to eradicate malaria. Sexual differentiation is essential for this process, as only sexual parasites, called gametocytes [...] activation of sexual-stage-specific transcription and gametocyte formation. Our results reveal that malaria parasites can sense and process host-derived physiological signals to regulate differentiation. These [...] of the sexual differentiation pathway in Plasmodium that may provide...
Mapping multiple components of malaria risk for improved targeting of elimination interventions (Publications)
component, related mappable malaria metrics are also described which may be measured and evaluated by malaria programmes seeking to better understand the determinants of malaria risk. Implementing tailored [...] There is a long history of considering the constituent components of malaria risk and the malaria transmission cycle via the use of mathematical models, yet strategic planning in endemic countries tends [...] tends not to take full advantage of available disease intelligence to tailor...
Impact of climate variability on the transmission risk of malaria in northern Côte d'Ivoire (Publications)
climate patterns might affect the transmission of malaria. The purpose of this study was to analyze climate and environmental parameters associated with malaria transmission in Korhogo, a city in northern Cote [...] (95% CI: 0.1 to 6.7%) in clinical malaria episodes. A 0.1 unit increase in monthly NDVI was associated with a 7.3% (95% CI: 0.8 to 14.1%) increase in the monthly malaria count. There was a similar increase [...] 2.3% to 11.2%)). The study results can be used to establish a malaria...
Mathematical modelling of the impact of expanding levels of malaria control interventions on <em>Plasmodium vivax</em> (Publications)
Plasmodium vivax poses unique challenges for malaria control and elimination, notably the potential for relapses to maintain transmission in the face of drug-based treatment and vector control strategies
Applied mathematical modelling to inform national malaria policies, strategies and operations in Tanzania (Publications)
data, and analytical tools for developing malaria control strategies as the heterogeneity in malaria risk within countries is increasing, and the available malaria control tools are expanding while large [...] the revision of the national malaria strategic plan with interventions targeted to the malaria risk at the sub-regional level. As part of the revision, a mathematical malaria modelling framework for setting [...] study article describes the long-term use of modelling in close collaboration...