Heterogeneous distribution of <em>Plasmodium falciparum</em> drug resistance haplotypes in subsets of the host population (Publications)
BACKGROUND: The emergence of drug resistance is a major problem in malaria control. For mathematical modelling of the transmission and spread of drug resistance the determinant parameters need to be identified
Isothermal microcalorimetry, a new tool to monitor drug action against <em>Trypanosoma brucei</em> and <em>Plasmodium falciparum</em> (Publications)
the toolbox for drug discovery for protozoal diseases such as human African trypanosomiasis and malaria. The method could probably be adapted to other protozoan parasites, especially those growing ext
Identification of a cis-acting DNA-protein interaction implicated in singular var gene choice in <em>Plasmodium falciparum</em> (Publications)
Plasmodium falciparum is responsible for the most severe form of malaria in humans. Antigenic variation of P. falciparum erythrocyte membrane protein 1 leads to immune evasion and occurs through switches
An efficient system to generate monoclonal antibodies against membrane-associated proteins by immunisation with antigen-expressing mammalian cells (Publications)
present study, we applied this approach successfully for three predicted GPI-anchored proteins of the malaria parasite Plasmodium falciparum. CONCLUSIONS: The described entirely cell-based technology is a fast
<em>Plasmodium falciparum</em> centromeres display a unique epigenetic makeup and cluster prior to and during schizogony (Publications)
organisms. The centromeres of Plasmodium falciparum, the causative agent of the most severe form of malaria have been broadly mapped on most chromosomes, but their epigenetic composition remained undefined
Heterogeneous distribution of <em>Plasmodium falciparum</em> drug resistance haplotypes in subsets of the host population (Publications)
BACKGROUND: The emergence of drug resistance is a major problem in malaria control. For mathematical modelling of the transmission and spread of drug resistance the determinant parameters need to be identified
Isothermal microcalorimetry, a new tool to monitor drug action against <em>Trypanosoma brucei</em> and <em>Plasmodium falciparum</em> (Publications)
the toolbox for drug discovery for protozoal diseases such as human African trypanosomiasis and malaria. The method could probably be adapted to other protozoan parasites, especially those growing ext
An efficient system to generate monoclonal antibodies against membrane-associated proteins by immunisation with antigen-expressing mammalian cells (Publications)
present study, we applied this approach successfully for three predicted GPI-anchored proteins of the malaria parasite Plasmodium falciparum. CONCLUSIONS: The described entirely cell-based technology is a fast
Enrichment of a single clone from a high diversity library of phage-displayed antibodies by panning with<em> Anopheles gambiae </em>(Diptera:... (Publications)
suggest that the selection of sufficiently diverse antibody panels, from which mosquitocidal or malaria transmission-blocking antibodies can be isolated, may require improved selection methods or specifically
Genetic analysis of IgG subclass responses against RESA and MSP2 of <em>Plasmodium falciparum</em> in adults in Papua New Guinea (Publications)
complex than governed by a single major gene. Such host genetic variation in responses to specific malaria antigens has implications for immuno-epidemiology and vaccine development