Host cytoskeleton remodeling throughout the blood stages of <em>Plasmodium falciparum</em> (Publications)
asexual intraerythrocytic development of Plasmodium falciparum, causing the most severe form of human malaria, is marked by extensive host cell remodeling. Throughout the processes of invasion, intracellular
Antiplasmodial and antitrypanosomal activity of new esters and ethers of 4-dialkylaminobicyclo[2.2.2]octan-2-ols (Publications)
suffer from painful application, severe side effects and increasing resistance against these drugs. Malaria tropica kills more than 2 million people every year mainly due to growing drug resistance. 4-Dia
Antiprotozoal activities of some constituents of <em>Markhamia tomentosa</em> (Bignoniaceae) (Publications)
bloodstream trypomastigotes of Trypanosoma brucei rhodesiense (the species responsible for human malaria, visceral leishmaniasis and African trypanosomiasis, respectively). Although compounds 1 and 2 exhibited
A <em>Plasmodium falciparum</em> bromodomain protein regulates invasion gene expression (Publications)
expression of invasion genes and indicate that targeting PfBDP1 could be an invaluable tool in malaria eradication
Predictors of residual antimalarial drugs in the blood in community surveys in Tanzania (Publications)
cross-sectional survey was conducted in 2015 in three regions of Tanzania with different levels of malaria endemicity. Interviews were conducted and blood samples collected through household surveys for further
Systems Performance and Monitoring (Page)
https://www.swisstph.ch/en/about/scih/systems-performance-and-monitoring
AIDS, Tuberculosis and Malaria created in 2002 to significantly increase resources to fight the three of the world's most devastating diseases (HIV and AIDS, Tuberculosis, and Malaria), and to direct those [...] adults. Am J Trop Med Hyg . 2023;109(1):138-146. DOI: 10.4269/ajtmh.22-0773 Related Topics HIV / AIDS Malaria Neglected Tropical Diseases (NTDs) Tuberculosis Related Activities Consultancy and Policy Advice
Vector Biology | Research at Swiss TPH (Page)
https://www.swisstph.ch/en/about/eph/vector-biology
particularly important vectors as they spread some of the most devastating infectious diseases such as malaria, dengue fever, West Nile fever or Zika virus infections. Investigation of Vectors and Development
<em>In vitro</em> assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of <em>Plasmodium falciparum</em> (Publications)
OBJECTIVES: Using synchronous cultures of Plasmodium falciparum malaria, the stage sensitivity of the parasite to OZ277 (RBx-11160), the first fully synthetic antimalarial peroxide that has entered Phase
Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals (Publications)
such as the semisynthetic artemisinins are critically important in the treatment of drug-resistant malaria. Nevertheless, their peroxide bond-dependent mode of action is still not well understood. Using
Insecticide susceptibility of <em>Anopheles </em>mosquitoes changes in response to variations in the larval environment (Publications)
Insecticide resistance threatens the success achieved through vector control in reducing the burden of malaria. An understanding of insecticide resistance mechanisms would help to develop novel tools and strategies
