Identification and profiling of a novel diazaspiro[3.4]octane chemical series active against multiple stages of the human malaria parasite... (Publications)
A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycl
Real-time dispersal of malaria vectors in rural Africa monitored with lidar (Publications)
observation of mosquito behavior with high spatio-temporal resolution limits progress towards improved malaria vector control. We deployed a high-resolution entomological lidar to monitor a half-kilometer static [...] this study demonstrate how lidar-based monitoring could dramatically improve our understanding of malaria vector ecology and control options.
Investigation of heterochromatin protein 1 function in the malaria parasite <em>Plasmodium falciparum</em> using a conditional domain deletion and... (Publications)
offers a tool for further studies on epigenetic regulation and life cycle decision in malaria parasites.IMPORTANCE Malaria is caused by unicellular Plasmodium species parasites that repeatedly invade and replicate [...] The human malaria parasite Plasmodium falciparum encodes a single ortholog of heterochromatin protein 1 (PfHP1) that plays a crucial role in the epigenetic regulation of various survival-related processes [...] domain and CSD of HP1 are functionally conserved between P....
Fine-scale distribution of malaria mosquitoes biting or resting outside human dwellings in three low-altitude Tanzanian villages (Publications)
investigated the distribution of malaria mosquitoes biting or resting outside dwellings in three low-altitude villages in south-eastern Tanzania. The likelihood of malaria infections outdoors was also assessed [...] proportion of non-human blood-meals and absence of malaria-infected mosquitoes after 12 months of nightly trapping suggests very low-levels of outdoor malaria transmission in these villages. [...] BACKGROUND: While malaria transmission in Africa still happens primarily inside houses,...
A stable, oligosymptomatic malaria focus in Thailand (Publications)
residents of a non-migratory farming village in south-eastern Thailand was visually examined for malaria parasites monthly for 2 years. Nearly 97% of the population had at least one (median = 5) patent [...] negative. The spleen rate (89% stage 1) was 24% in those under 15 years old and 7% in those older. No malaria mortality was seen P. falciparum cases treated for 10 d with quinine+tetracycline (QT) cleared the [...] better with MSP than with QT. The role played by hyperendemic, cryptic foci...
Leucopenia and abnormal liver function in travellers on malaria chemoprophylaxis (Publications)
Of 2887 travellers between the years 1984-1985, 451 on prophylactic antimalarials were studied retrospectively for adverse haematological or hepatic drug reactions and compared to 296 drug non-users.
Die Falciparum-Malaria in der Schweiz: ein Problem der Intensivmedizin? (Publications)
the period 1972-1976, 5 of 17 patients admitted to the Cantonal Hospital, Basel, for falciparum malaria had to be treated in the intensive care unit. Two patients died. None had performed regular chem [...] several days had elapsed between onset of symptoms and diagnosis. The importance of information on malaria to tourists and physicians is stressed.
