Speech and language sequelae of severe malaria in Kenyan children (Publications)
impairments following severe malaria in Kenyan children. RESEARCH DESIGN: Cohort study comparing the prevalence of impairments in children exposed or unexposed to severe malaria. METHODS AND PROCEDURES: The [...] study recruited 25 children who had previously been admitted to hospital with severe falciparum malaria and 27 unexposed to the disease. Assessments of comprehension, syntax, lexical semantics, higher [...] at 8-9 years of age, at least 2 years after admission to hospital in children...
Randomised trial of SPf66 vaccine against <em>Plasmodium falciparum</em> malaria in children in southern Tanzania (Publications)
3 clinical fever episodes per year. Minimum estimated community rates for serious malaria (cerebral malaria or malaria and anaemia) affect approximatively 5% of all children. Under conditions of a field [...] current malaria control strategies using rapid diagnosis and treatment as well as methods to reduce the man-vector contact have had limited success. In Kilombero district (Southern Tanzania), malaria transmission [...] Malaria, especially that due to Plasmodium falciparum, is one of the...
<em>Plasmodium falciparum </em>malaria disease manifestations in humans and transmission to<em> Anopheles gambiae</em>: a field study in Western Kenya (Publications)
Transmission of the malaria parasite Plasmodium is influenced by many different host, vector and parasite factors. Here we conducted a field study at Mbita, an area of endemic malaria in Western Kenya, to [...] to test whether parasite transmission to mosquitoes is influenced by the severity of malaria infection in its human host at the time when gametocytes, the transmission forms, are present in the peripheral [...] Plasmodium falciparum gametocyte carriers to mosquitoes. Of these, 21 were...
The malaria vaccine development programme in Papua New Guinea (Publications)
(PNGIMR), Papua New Guinea has a significant role in the global effort to develop a malaria vaccine, ensuring that the malaria patterns in Asia and the Pacific region are considered in vaccine development
Parasitological and clinical efficacy of standard treatment regimens against <em>Plasmodium falciparum</em>, <em>P. vivax</em> and <em>P.... (Publications)
(Q+SP) for malaria in a rural health centre of the East Sepik Province. 179 patients presenting with symptoms and signs of malaria and with Pf (144 patients), Pv (18 patients), P. malariae (Pm) (7 patients) [...] provided support for the recent change in the policy for the standard treatment of uncomplicated malaria in PNG from AQ or CQ to the combination of AQ+SP or CQ+SP, a recommendation aimed at slowing down
An individual-based model of <em>Plasmodium falciparum</em> malaria transmission on the coast of Kenya (Publications)
paper presents an object-oriented design for individual-based modelling of Plasmodium falciparum malaria transmission. Two kinds of objects, human and mosquito, that exhibit variability among individuals [...] intermediate and high transmission based on mean daily human-biting rates. Simulation results show that malaria transmission was stable even in low transmission areas where the human-biting rate is approximately [...] active case detection and drug treatment of infections. With this...