Preparation of antimalarial endoperoxides by a formal [2 + 2 + 2] cycloaddition (Publications)
A formal [2 + 2 + 2] cycloaddition reaction between a 1,3-dione, an olefin, and molecular oxygen mediated by light is reported, which delivers endoperoxides in good yield through the formation of two
Childhood cancer and residential exposure to highways: a nationwide cohort study (Publications)
Children living near highways are exposed to higher concentrations of traffic-related carcinogenic pollutants. Several studies reported an increased risk of childhood cancer associated with traffic ex
Is <em>Caenorhabditis elegans</em> the magic bullet for anthelminthic drug discovery? (Publications)
Recent advances in handling and readout have facilitated high-throughput screens with Caenorhabditis elegans. A new study demonstrates that C. elegans is a useful tool in high-throughput anthelminthic
A novel isothermal microcalorimetry tool to assess drug effects on<em> Ancylostoma ceylanicum</em> and <em>Necator americanus</em> (Publications)
Soil-transmitted helminths, which affect the poorest communities, worldwide cause a range of symptoms and morbidity, yet few treatment options are available and drug resistance is a concern. To improv
Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled,... (Publications)
BACKGROUND: The ongoing Ebola outbreak led to accelerated efforts to test vaccine candidates. On the basis of a request by WHO, we aimed to assess the safety and immunogenicity of the monovalent, reco
Extrinsic skin ageing in German, Chinese and Japanese women manifests differently in all three groups depending on ethnic background, age and... (Publications)
BACKGROUND: It has been suggested that extrinsic skin ageing manifests differently in Caucasians versus East Asians. In particular, from previous studies it was concluded that Caucasians are more pron
Limited value of whole blood Xpert® MTB/RIF for diagnosing tuberculosis in children (Publications)
OBJECTIVES: We evaluated the ability of the Xpert(R) MTB/RIF assay to detect Mycobacterium tuberculosis in whole blood of children with tuberculosis in tuberculosis endemic settings with high rates of