Discovery of inhibitors of<em> Trypanosoma brucei</em> by phenotypic screening of a focused protein kinase library (Publications)
A screen of a focused kinase inhibitor library against Trypanosoma brucei rhodesiense led to the identification of seven series, totaling 121 compounds, which showed > 50 % inhibition at 5 muM. Screen
Still far from 90-90-90: virologic outcomes of children on antiretroviral therapy in nurse-led clinics in rural Lesotho (Publications)
This survey assessed virologic outcomes of children on antiretroviral therapy and potential predictors in 10 nurse-led clinics in Lesotho. Success was achieved in 72% of the 191 children. No predictor
Matching comprehensive health insurance reimbursements to their real costs: the case of antenatal care visits in a region of Peru (Publications)
BACKGROUND: Prepaid contributory systems are increasingly being recognized as key mechanisms in achieving universal health coverage in low and middle-income countries. Peru created the Seguro Integral
Diversity of exophillic acid derivatives in strains of an endophytic <em>Exophiala</em> sp. (Publications)
Members of the fungal genus Exophiala are common saprobes in soil and water environments, opportunistic pathogens of animals, or endophytes in plant roots. Their ecological versatility could imply a c
Antimalarial benzoheterocyclic 4-aminoquinolines: structure-activity relationship, in vivo evaluation, mechanistic and bioactivation studies (Publications)
A novel class of benzoheterocyclic analogues of amodiaquine designed to avoid toxic reactive metabolite formation was synthesized and evaluated for antiplasmodial activity against K1 (multidrug resist
A blueprint to address research gaps in the development of biomarkers for pediatric tuberculosis (Publications)
Childhood tuberculosis contributes significantly to the global tuberculosis disease burden but remains challenging to diagnose due to inadequate methods of pathogen detection in paucibacillary pediatr