Benzo[b]quinolizinium derivatives have a strong antimalarial activity and inhibit indoleamine dioxygenase (Publications)
The heme-containing enzymes indoleamine 2,3-dioxygenase-1 and -2 (IDO-1, -2) catalyze the conversion of the essential amino acid tryptophan into kynurenine. Metabolites of the kynurenine pathway and I
Prevalence of malaria across Papua New Guinea after initial roll-out of insecticide-treated mosquito nets (Publications)
OBJECTIVES: To assess the population prevalence of malaria in villages across Papua New Guinea (PNG) following the first roll-out of free long-lasting insecticidal nets (LLIN). METHODS: Between Octobe
Clinical and epidemiologic phenotypes of childhood asthma (Publications)
Rationale: Clinical and epidemiologic approaches have identified two distinct sets of classifications for asthma and wheeze phenotypes. Objective: To compare epidemiologic phenotype definitions identi
A novel multiple-instance learning-based approach to computer-aided detection of tuberculosis on chest x-rays (Publications)
In order to reach performance levels comparable to those of human experts, computer-aided detection (CAD) systems are typically optimized by means of a supervised learning approach that relies on larg
Protection from childhood asthma and allergy in Alpine farm environments - the GABRIEL Advanced Studies (Publications)
BACKGROUND: Studies on the association of farm environments with asthma and atopy have repeatedly observed a protective effect of farming. However, no single specific farm-related exposure explaining
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children (Publications)
Background An ongoing phase 3 study of the efficacy, safety, and immunogenicity of candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries. Methods From March 2009 through J
