Prenatal farm exposure is related to the expression of receptors of the innate immunity and to atopic sensitization in school-age children (Publications)
BACKGROUND: There is increasing evidence that environmental exposures determining childhood illnesses operate early in life. Prenatal exposure to a farming environment through the mother might also pl
8,8-dialkyldihydroberberines with potent antiprotozoal activity (Publications)
Semisynthetic 8,8-dialkyldihydroberberines (8,8-DDBs) were found to possess mid- to low-nanomolar potency against Plasmodium falciparum blood-stage parasites, Leishmania donovani intracellular amastig
<em>In vivo</em> and <em>in vitro</em> sensitivity of <em>Fasciola hepatica</em> to combinations of triclabendazole and artesunate, artemether or OZ78 (Publications)
Triclabendazole resistance is continually documented from livestock and hence new treatment strategies for F. hepatica infections are needed. We investigated the effect of combinations with triclabend
Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with <em>Fasciola hepatica</em> (Publications)
The pharmacokinetic (PK) parameters of artesunate, artemether and their metabolites dihydroartemisinin (DHA) and dihydroartemisinin-glucuronide (DHA-glucuronide) were determined in sheep naturally inf
<em>Fasciola hepatica</em>: comparison of the sedimentation and FLOTAC techniques for the detection and quantification of faecal egg counts in rats (Publications)
We compared the sedimentation and FLOTAC techniques for the detection and quantification of Fasciola hepatica eggs in faecal samples obtained from 120 experimentally-infected rats before intervention,
Abietane diterpenoids from <em>Salvia sahendica</em> - antiprotozoal activity and determination of their absolute configurations (Publications)
In a screening of Iranian plants for antiprotozoal activity, an n-hexane extract of the roots of Salvia sahendica potently inhibited the growth of Plasmodium falciparum K1 strain. Subsequent HPLC-base
Participatory mapping of target areas to enable operational larval source management to suppress malaria vector mosquitoes in Dar es Salaam, Tanzania (Publications)
ABSTRACT: BACKGROUND: Half of the population of Africa will soon live in towns and cities where it can be protected from malaria by controlling aquatic stages of mosquitoes. Rigorous but affordable an
The structure-activity relationship of the antimalarial ozonide arterolane (OZ277) (Publications)
The structure and stereochemistry of the cyclohexane substituents of analogues of arterolane (OZ277) had little effect on potency against Plasmodium falciparum in vitro. Weak base functional groups we