Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in <em>Plasmodium falciparum</em> (Publications)
Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), encoded by the var gene family, undergoes antigenic variation and plays an important role in chronic infection and severe malaria. Only a
<em>Plasmodium</em> gene regulation: far more to factor in (Publications)
Gene expression in the malaria parasite has received generous attention over the past several decades, predominantly because of the importance of var gene regulation, which is key to antigenic variati
New drugs for the treatment of human African trypanosomiasis: research and development (Publications)
Chemotherapy of human African trypanosomiasis is problematic because of the high frequency of severe adverse events, the long duration and high cost of treatment, and an increasing number of treatment
Topoisomerases in kinetoplastids (Publications)
Topoisomerases are enzymes that mediate topological changes in DNA that are essential for nucleic acid biosynthesis and for cell survival. The kinetoplastid protozoa, which include pathogenic trypanos