Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents (Publications)
The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent
Diagnostic accuracy of a LAMP kit for diagnosis of imported malaria in Switzerland (Publications)
BACKGROUND: The diagnosis of acute malaria in non-endemic countries is still carried out largely by microscopic examination of thick and thin smears or rapid diagnostic tests. Low-density infections m
Impact of malaria pre-exposure on anti-parasite cellular and humoral immune responses after controlled human malaria infection (Publications)
To understand the effect of previous malaria exposure on anti-parasite immune responses is important for developing successful immunization strategies. Controlled human malaria infections (CHMI) using
Contemporary and emerging strategies for eliminating human African trypanosomiasis due to <em>Trypanosoma brucei brucei gambiense</em> (Publications)
OBJECTIVES: To review current and emerging tools for Gambiense HAT control and elimination, and propose strategies that integrate these tools with epidemiological evidence. METHODS: We reviewed the sc
Prodrugs of reverse fosmidomycin analogues (Publications)
Fosmidomycin inhibits IspC (Dxr, 1-deoxy-d-xylulose 5-phosphate reductoisomerase), a key enzyme in nonmevalonate isoprenoid biosynthesis that is essential in Plasmodium falciparum. The drug has been u
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188... (Publications)
BACKGROUND: Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national he
Are well functioning civil registration and vital statistics systems associated with better health outcomes? (Publications)
In this Series paper, we examine whether well functioning civil registration and vital statistics (CRVS) systems are associated with improved population health outcomes. We present a conceptual model
Progress with <em>Plasmodium falciparum </em>sporozoite (PfSPZ)-based malaria vaccines (Publications)
Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to develop an injectable PfSPZ-ba
Ability of physicians to diagnose influenza and usefulness of a rapid influenza antigen test in febrile returning travelers: a randomized controlled... (Publications)
BACKGROUND: Fever is a frequent cause of medical consultation among returning travelers. The objectives of this study were to assess whether physicians were able to identify patients with influenza an
