The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation (Publications)
Newly assembled dengue viruses (DENV) undergo maturation to become infectious particles. The maturation process involves major rearrangement of virus surface premembrane (prM) and envelope (E) protein
The 1992-1999 World Bank Schistosomiasis Research Initiative in China: outcome and perspectives (Publications)
Ongoing efforts over the last 50 years, aiming at the elimination of schistosomiasis in the People's Republic of China, have been spectaculary successful in reducing the prevalence and intensity of th
Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL) (Publications)
Anti-Leishmania in vitro and in vivo activities of various rhodacyanine derivatives have been examined. Among them, the fluorinatied variant SJL-01 (8) showed IC(50) of 0.011 microM against Leishmania
Tegumental changes in adult <em>Schistosoma mansoni</em> harboured in mice treated with praziquantel enantiomers (Publications)
Praziquantel administered to the host causes damage to the tegument of Schistosoma mansoni. In this study, the effects of racemic praziquantel (Pra) and its enantiomers, levo-praziquantel (L-Pra) and
Structure-activity relationships for ferriprotoporphyrin IX association and beta-hematin inhibition by 4-aminoquinolines using experimental and <em>ab... (Publications)
In order to probe structure-activity relationships of association with ferriprotoporphyrin IX (logK) and inhibition of ?-hematin formation, a series of 4-aminoquinolines with varying substituents at t